ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2009
Prenatal programming of rat thick ascending limb chloride transport by low-protein diet and dexamethasone.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Thallium reabsorption via NKCC2 causes severe acute kidney injury with outer medulla-specific calcium crystal casts in rats.Archives of toxicology · 2024Article
- Sex differences in prenatal programming of hypertension by dexamethasone.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Impact of early-life diet on long-term renal health.Molecular and cellular pediatrics · 2020Review
- Review
- Role of renal sympathetic nerve activity in prenatal programming of hypertension.Pediatric nephrology (Berlin, Germany) · 2018Review
- Primary Pediatric Hypertension: Current Understanding and Emerging Concepts.Current hypertension reports · 2017Review
- Luminal angiotensin II stimulates rat medullary thick ascending limb chloride transport in the presence of basolateral norepinephrine.American journal of physiology. Renal physiology · 2016Article
- Understanding the role of maternal diet on kidney development; an opportunity to improve cardiovascular and renal health for future generations.Nutrients · 2015Review
- Effect of prenatal programming and postnatal rearing on glomerular filtration rate in adult rats.American journal of physiology. Renal physiology · 2015Article
- Transient Exposure of Enalapril Normalizes Prenatal Programming of Hypertension and Urinary Angiotensinogen Excretion.PloS one · 2015Article
- Review
- Effect of postnatal maternal protein intake on prenatal programming of hypertension.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
- Perinatal growth restriction decreases diuretic action of furosemide in adult rats.European journal of pharmacology · 2014Article
- Enalapril attenuates the exaggerated sympathetic response to physical stress in prenatally programmed hypertensive rats.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Impaired ability to modulate glomerular filtration rate in aged female sheep following fetal uninephrectomy.Physiological reports · 2014Article
- How the kidney is impacted by the perinatal maternal environment to develop hypertension.Biology of reproduction · 2013Review
- Prenatal programming of hypertension induces sympathetic overactivity in response to physical stress.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Prenatal programming of rat cortical collecting tubule sodium transport.American journal of physiology. Renal physiology · 2012Article
- Segmental sodium reabsorption by the renal tubule in prenatally programmed hypertension in the rat.Pediatric nephrology (Berlin, Germany) · 2012Article
- Mechanisms of fetal programming in hypertension.International journal of pediatrics · 2012Article
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5 authors.
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Abstract
Prenatal administration of dexamethasone and a low-protein diet has been shown to result in hypertension in the offspring when they are adults. The cause for the hypertension is unknown. The purpose of this study was to examine whether there was prenatal programming of thick ascending limb transport. Rats were administered either dexamethasone for 4 days (0.2 mg/kg body wt) by intraperitoneal injection daily between the 15th and 18th day of gestation, or they were fed a low-protein diet (6% protein) or an isocaloric normal protein diet (20% protein) from day 12 gestation until birth. The offspring were studied as adults. Prenatal dexamethasone and dietary protein deprivation resulted in an increase in blood pressure. Offspring of mothers fed a low-protein diet had an increase in medullary but not cortical bumetanide-sensitive Na-K-2Cl cotransporter (NKCC2) protein abundance (P < 0.01). There was not a statistically significant increase in medullary NKCC2 by prenatal dexamethasone (P = 0.07). Both prenatal administration of dexamethasone and a low-protein diet resulted in an increase in medullary thick ascending limb chloride transport compared with control (298 +/- 33 pmoles x mm(-1) x min(-1), 280 +/- 26 pmoles x mm(-1) x min(-1), and 191 +/- 21 pmoles x mm(-1) x min(-1), respectively P < 0.05). There was a higher lumen-positive transepithelial potential difference in the prenatal dexamethasone and low-protein group compared with control as well. Administration of furosemide for 24 h resulted in a decrease in blood pressure in the low-protein group but not the control group. This study demonstrates that insults administered to the fetus can program altered sodium transport. Increased tubular sodium transport is a likely cause for the hypertension by prenatal programming.
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