ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
SRC family kinases are required for limb trajectory selection by spinal motor axons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- c-Kit Receptor Maintains Sensory Axon Innervation of the Skin through Src Family Kinases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Paxillin Is Required for Proper Spinal Motor Axon Growth into the Limb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Geometry of Limb Motor Innervation is Controlled by the Dorsal-Ventral Compartment Boundary in the Chick Limbless Mutant.Neuroscience · 2020Article
- Ephrin-A5 potentiates netrin-1 axon guidance by enhancing Neogenin availability.Scientific reports · 2019Article
- The endosomal sorting adaptor HD-PTP is required for ephrin-B:EphB signalling in cellular collapse and spinal motor axon guidance.Scientific reports · 2019Article
- Ephexin1 Is Required for Eph-Mediated Limb Trajectory of Spinal Motor Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The developmental and genetic basis of 'clubfoot' in the peroneal muscular atrophy mutant mouse.Development (Cambridge, England) · 2018Article
- Mechanisms of ephrin-Eph signalling in development, physiology and disease.Nature reviews. Molecular cell biology · 2016Review
- Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons.eLife · 2015Article
- EphrinB2 sharpens lateral motor column division in the developing spinal cord.Neural development · 2015Article
- Src and cortactin promote lamellipodia protrusion and filopodia formation and stability in growth cones.Molecular biology of the cell · 2015Article
- SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons.Neurotoxicity research · 2015Article
- α2-chimaerin is required for Eph receptor-class-specific spinal motor axon guidance and coordinate activation of antagonistic muscles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Plasticity versus specificity in RTK signalling modalities for distinct biological outcomes in motor neurons.BMC biology · 2014Article
- Emergence of motor circuit activity.PloS one · 2014Article
- Genetic analysis of DSCAM's role as a Netrin-1 receptor in vertebrates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling.PLoS biology · 2010Article
- Signaling from axon guidance receptors.Cold Spring Harbor perspectives in biology · 2010Review
- Motor axon pathfinding.Cold Spring Harbor perspectives in biology · 2010Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signal relay by guidance receptors at the axonal growth cone is a process essential for the assembly of a functional nervous system. We investigated the in vivo function of Src family kinases (SFKs) as growth cone guidance signaling intermediates in the context of spinal lateral motor column (LMC) motor axon projection toward the ventral or dorsal limb mesenchyme. Using in situ mRNA detection we determined that Src and Fyn are expressed in LMC motor neurons of chick and mouse embryos at the time of limb trajectory selection. Inhibition of SFK activity by C-terminal Src kinase (Csk) overexpression in chick LMC axons using in ovo electroporation resulted in LMC axons selecting the inappropriate dorsoventral trajectory within the limb mesenchyme, with medial LMC axon projecting into the dorsal and ventral limb nerve with apparently random incidence. We also detected LMC axon trajectory choice errors in Src mutant mice demonstrating a nonredundant role for Src in motor axon guidance in agreement with gain and loss of Src function in chick LMC neurons which led to the redirection of LMC axons. Finally, Csk-mediated SFK inhibition attenuated the retargeting of LMC axons caused by EphA or EphB over-expression, implying the participation of SFKs in Eph-mediated LMC motor axon guidance. In summary, our findings demonstrate that SFKs are essential for motor axon guidance and suggest that they play an important role in relaying ephrin:Eph signals that mediate the selection of motor axon trajectory in the limb.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.