ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
p75 and TrkA signaling regulates sympathetic neuronal firing patterns via differential modulation of voltage-gated currents.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Spared but Not Silent: Ion Channel Plasticity in Uninjured Sensory Neurons in Neuropathic Pain.International journal of molecular sciences · 2026Review
- Cancer-induced nerve injury unveils a sympathetic-to-sensory nerve axis in a mouse model of head and neck squamous cell carcinoma.Science translational medicine · 2026Article
- Satellite Glial Cells Drive Homeostatic Synaptic Structural Plasticity in Sympathetic Neurons.bioRxiv : the preprint server for biology · 2026Article
- Identification of Phenotypically Distinct Cancer Stem Cell Subpopulations in Oral Squamous Cell Carcinoma.Cancers · 2025Article
- NgfrNature communications · 2024Article
- Extraocular Motoneurons and Neurotrophism.Advances in neurobiology · 2022Article
- Heightened sympathetic neuron activity and altered cardiomyocyte properties in spontaneously hypertensive rats during the postnatal period.Frontiers in synaptic neuroscience · 2022Article
- Healthy cardiac myocytes can decrease sympathetic hyperexcitability in the early stages of hypertension.Frontiers in synaptic neuroscience · 2022Article
- Downregulation of M Current Is Coupled to Membrane Excitability in Sympathetic Neurons Before the Onset of Hypertension.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Near-infrared light-triggered NO release for spinal cord injury repair.Science advances · 2020Article
- A Calcium-Dependent Chloride Current Increases Repetitive Firing in Mouse Sympathetic Neurons.Frontiers in physiology · 2018Article
- Presence of Functional Neurotrophin TrkB Receptors in the Rat Superior Cervical Ganglion.Frontiers in physiology · 2017Article
- Functional Diversity of Neurotrophin Actions on the Oculomotor System.International journal of molecular sciences · 2016Review
- Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease.The Journal of physiology · 2016Review
- Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex.Molecular brain · 2016Article
- Molecular Mechanisms of Sympathetic Remodeling and Arrhythmias.Circulation. Arrhythmia and electrophysiology · 2016Review
- proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Virtual leak channels modulate firing dynamics and synaptic integration in rat sympathetic neurons: implications for ganglionic transmission in vivo.The Journal of physiology · 2015Article
- Nerve growth factor sensitizes adult sympathetic neurons to the proinflammatory peptide bradykinin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- TNF-α/TNFR1 signaling is required for the development and function of primary nociceptors.Neuron · 2014Article
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2 authors.
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Abstract
Neurotrophins such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) act through the tropomyosin-related receptor tyrosine kinases (Trk) and the pan-neurotrophin receptor (p75) to regulate complex developmental and functional properties of neurons. While NGF activates both receptor types in sympathetic neurons, differential signaling through TrkA and p75 can result in widely divergent functional outputs for neuronal survival, growth, and synaptic function. Here we show that TrkA and p75 signaling pathways have opposing effects on the firing properties of sympathetic neurons, and define a mechanism whereby the relative level of signaling through these two receptors sets firing patterns via coordinate regulation of a set of ionic currents. We show that signaling through the p75 pathway causes sympathetic neurons to fire in a phasic pattern showing marked accommodation. Signaling through the NGF-specific TrkA, on the other hand, causes cells to fire tonically. Neurons switch rapidly between firing patterns, on the order of minutes to hours. We show that changes in firing patterns are caused by neurotrophin-dependent regulation of at least four voltage-gated currents: the sodium current and the M-type, delayed rectifier, and calcium-dependent potassium currents. Neurotrophin release, and thus receptor activation, varies among somatic tissues and physiological state. Thus, these data suggest that target-derived neurotrophins may be an important determinant of the characteristic electrical properties of sympathetic neurons and therefore regulate the functional output of the sympathetic nervous system.
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