ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Parallel use of two behavioral mechanisms for chemotaxis in Caenorhabditis elegans.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers.
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154 citing papers in PubMed.
- The Marginal Value Theorem inbioRxiv : the preprint server for biology · 2026Article
- Aging-related behavioral defects in Caenorhabditis elegans.Biology open · 2026Article
- Immobilization-free chemotaxis analysis reveals the novel behavioral mode of "leaving" inbioRxiv : the preprint server for biology · 2026Article
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- Neural sequences underlying directed turning in Caenorhabditis elegans.Nature neuroscience · 2026Article
- Experience-Dependent Gain Modulation Drives Thermosensory Responses in Behavior.bioRxiv : the preprint server for biology · 2026Article
- INS-17 acts as a nutrient deprivation signal to mediate adult IIS-regulated associative behaviors in C. elegans.PLoS genetics · 2026Article
- A lateralized sensory signaling pathway mediates context-dependent olfactory plasticity inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Efficient pheromone navigation via antagonistic detectors in Caenorhabditis elegans male.Nature communications · 2026Article
- INS-17, an insulin-receptor ligand, confers specificity in adult IIS-regulated phenotypes inbioRxiv : the preprint server for biology · 2025Article
- Beyond Binary: A Machine Learning Framework for Interpreting Organismal Behavior in Cancer Diagnostics.Biomedicines · 2025Review
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- Dissection of Behavioral Components and the Role of Omega/Delta Turns for the Chemotaxis of C. elegans.Genes to cells : devoted to molecular & cellular mechanisms · 2025Article
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- Sensory plasticity caused by up-down regulation encodes the information of short-term learning and memory.iScience · 2025Article
- Navigation strategies in Caenorhabditis elegans are differentially altered by learning.PLoS biology · 2025Article
- Aberrant neuronal hyperactivation causes an age-dependent behavioral decline inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neurexin drives Caenorhabditis elegans avoidance behavior independently of its post-synaptic binding partner neuroligin.G3 (Bethesda, Md.) · 2024Article
- Learning optimal integration of spatial and temporal information in noisy chemotaxis.PNAS nexus · 2024Article
94 more citing papers are in PubMed but not listed here.
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Caenorhabditis elegans shows chemotaxis to various odorants and water-soluble chemoattractants such as NaCl. Previous studies described the pirouette mechanism for chemotaxis, in which C. elegans quickly changes the direction of locomotion by using a set of stereotyped behaviors, a pirouette, in response to a decrease in the concentration of the chemical. Here, we report the discovery of a second mechanism for chemotaxis, called the weathervane mechanism. In this strategy animals respond to a spatial gradient of chemoattractant and gradually curve toward higher concentration of the chemical. By computer simulation, we find that both of these mechanisms contribute to chemotaxis and both mechanisms need to act in parallel for efficient chemotaxis. Using laser ablation of individual neurons to examine the underlying neural circuit, we find the ASE sensory neurons and AIZ interneurons are essential for both the pirouette and weathervane mechanisms in chemotaxis to NaCl. Salt-conditioned animals show reversed responses in both of these behaviors, leading to avoidance of NaCl. These results provide a platform for detailed molecular and cellular analyses of chemotaxis and its plasticity in this model organism.
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