ArticleLearning & memory (Cold Spring Harbor, N.Y.)2009
Intrahippocampal infusions of anisomycin produce amnesia: contribution of increased release of norepinephrine, dopamine, and acetylcholine.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
- Disrupting reconsolidation of fear memory in humans by a noradrenergic β-blocker.Journal of visualized experiments : JoVE · 2014Trial
- Cpeb1 remodels cell type-specific translational program to promote fear extinction.Science advances · 2025Article
- Identification of Causal Genes and Potential Drug Targets for Restless Legs Syndrome: A Comprehensive Mendelian Randomization Study.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Beyond reconsolidation: The need for a broad theoretical approach in clinical translations of research on retrieval-induced plasticity.Behavioral neuroscience · 2024Review
- Serotonin Signaling in Hippocampus during Initial Cocaine Abstinence Drives Persistent Drug Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Basal forebrain cholinergic systems as circuits through which traumatic stress disrupts emotional memory regulation.Neuroscience and biobehavioral reviews · 2024Review
- Phencyclidine Disrupts Neural Coordination and Cognitive Control by Dysregulating Translation.Biological psychiatry global open science · 2024Article
- Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation.Nature neuroscience · 2020Article
- The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics.Journal of neurophysiology · 2019Article
- Article
- The role of basal forebrain cholinergic neurons in fear and extinction memory.Neurobiology of learning and memory · 2016Review
- ZIP It: Neural Silencing Is an Additional Effect of the PKM-Zeta Inhibitor Zeta-Inhibitory Peptide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Cognition Enhancing and Neuromodulatory Propensity of Bacopa monniera Extract Against Scopolamine Induced Cognitive Impairments in Rat Hippocampus.Neurochemical research · 2016Article
- Intrahippocampal Anisomycin Impairs Spatial Performance on the Morris Water Maze.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Anisomycin in the medial prefrontal cortex reduces reconsolidation of cocaine-associated memories in the rat self-administration model.Neuropharmacology · 2015Article
- Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zero.Nature neuroscience · 2013Article
- Anisomycin infusions in the parabrachial nucleus and taste neophobia.Neurobiology of learning and memory · 2012Article
- Cycloheximide impairs and enhances memory depending on dose and footshock intensity.Behavioural brain research · 2012Article
- Neurochemical and neurobehavioral effects of low lead exposure on the developing brain.Indian journal of clinical biochemistry : IJCB · 2012Article
- Neurosilence: profound suppression of neural activity following intracerebral administration of the protein synthesis inhibitor anisomycin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Intra-amygdala injections of anisomycin produce large increases in the release of norepinephrine (NE), dopamine (DA), and serotonin in the amygdala. Pretreatment with intra-amygdala injections of the beta-adrenergic receptor antagonist propranolol attenuates anisomycin-induced amnesia without reversing the inhibition of protein synthesis, and injections of NE alone produce amnesia. These findings suggest that abnormal neurotransmitter responses may be the basis for amnesia produced by inhibition of protein synthesis. The present experiment extends these findings to the hippocampus and adds acetylcholine (ACh) to the list of neurotransmitters affected by anisomycin. Using in vivo microdialysis at the site of injection, release of NE, DA, and ACh was measured before and after injections of anisomycin into the hippocampus. Anisomycin impaired inhibitory avoidance memory when rats were tested 48 h after training and also produced substantial increases in local release of NE, DA, and ACh. In an additional experiment, pretreatment with intrahippocampal injections of propranolol prior to anisomycin and training significantly attenuated anisomycin-induced amnesia. The disruption of neurotransmitter release patterns at the site of injection appears to contribute significantly to the mechanisms underlying amnesia produced by protein synthesis inhibitors, calling into question the dominant interpretation that the amnesia reflects loss of training-initiated protein synthesis necessary for memory formation. Instead, the findings suggest that proteins needed for memory formation are available prior to an experience, and that post-translational modifications of these proteins may be sufficient to enable the formation of new memories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.