ArticleJournal of clinical microbiology2009
Comparison of a variable-number tandem-repeat (VNTR) method for typing Mycobacterium avium with mycobacterial interspersed repetitive-unit-VNTR and IS1245 restriction fragment length polymorphism typing.
Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 93 citations in OpenAlex.
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- New mini-satellite tandem repeat markers for strain typing of Mycobacterium avium subsp. paratuberculosis.Molecular biology reports · 2025Article
- Genotyping and drug susceptibility patterns of Mycobacterium avium subsp. hominissuis isolates from different hosts.Scientific reports · 2025Article
- Variability of macrolide-resistant profile inAntimicrobial agents and chemotherapy · 2024Article
- Bigger problems from smaller colonies: emergence of antibiotic-tolerant small colony variants of Mycobacterium avium complex in MAC-pulmonary disease patients.Annals of clinical microbiology and antimicrobials · 2024Article
- Unique genomic sequences in a novelOne health (Amsterdam, Netherlands) · 2023Article
- MGIT Enriched Shotgun Metagenomics for Routine Identification of Nontuberculous Mycobacteria: a Route to Personalized Health Care.Journal of clinical microbiology · 2023Article
- Mycobacteriosis in slaughter pigs from South Africa from 1991 to 2002:Frontiers in microbiology · 2023Article
- Phylogenetic and Multiple-Locus Variable number tandem repeat analysis of Mycobacterium avium subsp. paratuberculosis isolates from Argentina.Veterinary research communications · 2022Article
- Ten cases of Mycobacterium avium subsp. hominissuis infections linked to equine abortions in Japan, 2018-2019.Veterinary medicine and science · 2021Article
- Differential Genotyping ofMicroorganisms · 2020Review
- Applicability of using 15 MIRU-VNTR loci for genotyping of Mycobacterium avium subsp. paratuberculosis from two cattle farms in Egypt.Molecular biology reports · 2019Article
- The recombination-cold region as an epidemiological marker of recombinogenic opportunistic pathogen Mycobacterium avium.BMC genomics · 2019Article
- Genotyping of swine Mycobacterium avium subsp. hominissuis isolates from Kyushu, Japan.The Journal of veterinary medical science · 2019Article
- Mycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010-2012.Emerging infectious diseases · 2019Article
- Retrospective evaluation of natural course in mild cases of Mycobacterium avium complex pulmonary disease.PloS one · 2019Article
- Antibiotic Susceptibility and Genotyping of Mycobacterium avium Strains That Cause Pulmonary and Disseminated Infection.Antimicrobial agents and chemotherapy · 2018Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycobacterium avium complex (MAC) infections are increasing annually in various countries, including Japan, but the route of transmission and pathophysiology of the infection remain unclear. Currently, a variable-number tandem-repeat (VNTR) typing method using the Mycobacterium avium tandem repeat (MATR) loci (MATR-VNTR) is employed in Japan for epidemiological studies using clinical isolates of M. avium. In this study, the usefulness of this MATR-VNTR typing method was compared with that of the IS1245-restriction fragment length polymorphism (IS1245-RFLP) typing method and a mycobacterial interspersed repetitive-unit (MIRU)-VNTR typing method reported previously (V. C. Thibault, M. Grayon, M. L. Boschiroli, C. Hubbans, P. Overduin, K. Stevenson, M. C. Gutierrez, P. Supply, and F. Biet, J. Clin. Microbiol. 45:2404-2410, 2007). Seventy clinical isolates identified as M. avium from human immunodeficiency virus-negative patients with MAC infections were used. MATR-VNTR typing using 15 loci distinguished 56 patterns of different allele profiles, yielding a Hunter-Gaston discriminatory index (HGDI) of 0.990. However, IS1245-RFLP and MIRU-VNTR typing yielded HGDIs of 0.960 and 0.949, respectively, indicating that MATR-VNTR has an excellent discriminatory power compared with MIRU-VNTR and IS1245-RFLP typing. Moreover, concomitant use of the MATR-VNTR method and IS1245-RFLP typing increased the HGDI to 0.999. MATR-VNTR typing is inexpensive and easy to perform and could thus be useful in establishing a digital multifacility database that will greatly contribute to the clarification of the transmission route and pathophysiology of M. avium infections.
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