ArticleGenome research2009
The polyadenylation site of Mimivirus transcripts obeys a stringent 'hairpin rule'.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 68 citations in OpenAlex.
- The complexity landscape of viral genomes.GigaScience · 2022Article
- Role of an FNIP Repeat Domain-Containing Protein Encoded by Megavirus Baoshan during Viral Infection.Journal of virology · 2022Article
- Giant viruses of themicroLife · 2022Article
- Metatranscriptomics Analysis Reveals Diverse Viral RNA in Cutaneous Papillomatous Lesions of Cattle.Evolutionary bioinformatics online · 2022Article
- RNA Sequencing of Medusavirus Suggests Remodeling of the Host Nuclear Environment at an Early Infection Stage.Microbiology spectrum · 2021Article
- Metatranscriptome Library Preparation Influences Analyses of Viral Community Activity During a Brown Tide Bloom.Frontiers in microbiology · 2021Article
- Giant Mimiviridae CsCl Purification Protocol.Bio-protocol · 2020Article
- Elucidating micro RNAs role in different plant-pathogen interactions.Molecular biology reports · 2020Review
- Exploration of the propagation of transpovirons within Mimiviridae reveals a unique example of commensalism in the viral world.The ISME journal · 2020Article
- Review
- Article
- Stem-Loop RNA Hairpins in Giant Viruses: Invading rRNA-Like Repeats and a Template Free RNA.Frontiers in microbiology · 2018Article
- Ancestrality and Mosaicism of Giant Viruses Supporting the Definition of the Fourth TRUC of Microbes.Frontiers in microbiology · 2018Article
- Noumeavirus replication relies on a transient remote control of the host nucleus.Nature communications · 2017Article
- Mimivirus: leading the way in the discovery of giant viruses of amoebae.Nature reviews. Microbiology · 2017Review
- Evolution of Nucleotide Punctuation Marks: From Structural to Linear Signals.Frontiers in genetics · 2017Article
- Piecemeal Buildup of the Genetic Code, Ribosomes, and Genomes from Primordial tRNA Building Blocks.Life (Basel, Switzerland) · 2016Article
- Single-shot diffraction data from the Mimivirus particle using an X-ray free-electron laser.Scientific data · 2016Article
- CRISPR-Cas-like system in giant viruses: why MIMIVIRE is not likely to be an adaptive immune system.Virologica Sinica · 2016Article
- Exploiting tRNAs to Boost Virulence.Life (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mimivirus, a giant DNA virus infecting Acanthamoeba, is revealing an increasing list of unique features such as a 1.2-Mb genome with numerous genes not found in other viruses, a uniquely conserved promoter signal, and a particle of unmatched complexity using two distinct portals for genome delivery and packaging. Herein, we contribute a further Mimivirus distinctive feature discovered by sequencing a panel of viral cDNAs produced for probing the structure of Mimivirus transcripts. All Mimivirus mRNAs are polyadenylated at a site coinciding exactly with unrelated, but strongly palindromic, genomic sequences. The analysis of 454 Life Sciences (Roche) FLX cDNA tags (150,651) confirmed this finding for all Mimivirus genes independent of their transcription timings and expression levels. The absence of a suitable palindromic signal between adjacent genes results in transcripts encompassing multiple ORFs in the same or even in opposite orientations. Surprisingly, Mimivirus tRNAs are expressed as polyadenylated messengers, including an ORF/tRNA composite mRNA. To our knowledge, both the nature and the stringency of the "hairpin rule" defining the location of polyadenylation sites are unique, raising once more the question of Mimivirus's evolutionary origin. The precise molecular mechanisms implementing the hairpin rule into the 3'-end processing of Mimivirus pre-mRNAs remain to be elucidated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.