ArticleJournal of virology2009
Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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Who cites it
46 citing papers in PubMed, 79 citations in OpenAlex.
- Quantitative detection of amyloid fibrils using fluorescence resonance energy transfer between engineered yellow and cyan proteins.Protein science : a publication of the Protein Society · 2025Article
- Direct translation of incoming retroviral genomes.Nature communications · 2024Article
- Galectin-1 interacts with the human endogenous retroviral envelope protein syncytin-2 and potentiates trophoblast fusion in humans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Structure, function and antagonism of semen amyloids.Chemical communications (Cambridge, England) · 2018Review
- No detection of the retrovirus xenotropic murine leukemia virus-related virus in individuals with hemophilia.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2013Article
- Emerging roles of human prostatic Acid phosphatase.Biomolecules & therapeutics · 2013Review
- Short communication: RNASEL alleles and susceptibility to infection by human retroviruses and hepatitis viruses.AIDS research and human retroviruses · 2012Article
- Circumcision and the risk of prostate cancer.Cancer · 2012Article
- Inhibition of semen-derived enhancer of virus infection (SEVI) fibrillogenesis by zinc and copper.European biophysics journal : EBJ · 2012Article
- XMRV accelerates cellular proliferation, transformational activity, and invasiveness of prostate cancer cells by downregulating p27(Kip1).The Prostate · 2012Article
- A new hypothesis for the cancer mechanism.Cancer metastasis reviews · 2012Review
- Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP(248-286).The journal of physical chemistry. B · 2012Article
- Absence of XMRV and closely related viruses in primary prostate cancer tissues used to derive the XMRV-infected cell line 22Rv1.PloS one · 2012Article
- Susceptibility of human lymphoid tissue cultured ex vivo to xenotropic murine leukemia virus-related virus (XMRV) infection.PloS one · 2012Article
- Sensitivity of PCR assays for murine gammaretroviruses and mouse contamination in human blood samples.PloS one · 2012Article
- Article
- No biological evidence of XMRV in blood or prostatic fluid from prostate cancer patients.PloS one · 2012Article
- Infection, viral dissemination, and antibody responses of rhesus macaques exposed to the human gammaretrovirus XMRV.Journal of virology · 2011Article
- Severe restriction of xenotropic murine leukemia virus-related virus replication and spread in cultured human peripheral blood mononuclear cells.Journal of virology · 2011Article
- The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency.Biochimica et biophysica acta · 2011Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
The xenotropic murine leukemia virus-related virus (XMRV) has recently been detected in prostate cancer tissues and may play a role in tumorigenesis. It is currently unclear how this virus is transmitted and which factors promote its spread in the prostate. We show that amyloidogenic fragments known as semen-derived enhancer of virus infection (SEVI) originating from prostatic acid phosphatase greatly increase XMRV infections of primary prostatic epithelial and stromal cells. Hybrid simian/human immunodeficiency chimeric virus particles pseudotyped with XMRV envelope protein were used to demonstrate that the enhancing effect of SEVI, or of human semen itself, was at the level of viral attachment and entry. SEVI enhanced XMRV infectivity but did not bypass the requirement for the xenotropic and polytropic retrovirus receptor 1. Furthermore, XMRV RNA was detected in prostatic secretions of some men with prostate cancer. The fact that the precursor of SEVI is produced in abundance by the prostate indicates that XMRV replication occurs in an environment that provides a natural enhancer of viral infection, and this may play a role in the spread of this virus in the human population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.