ArticleDevelopment (Cambridge, England)2009
The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Revisiting gut microbiota-driven ammonia metabolism: from disease burden to physiological adaptation.Gut microbes · 2026Review
- Does the pancreas of gekkotans differentiate similarly? Developmental structural and 3D studies of the mourning gecko (Lepidodactylus lugubris) and the leopard gecko (Eublepharis macularius).Journal of anatomy · 2024Article
- The role of Tetraspanins in digestive system tumor development: update and emerging evidence.Frontiers in cell and developmental biology · 2024Review
- Tetraspanin CD9 interacts with α-secretase to enhance its oncogenic function in pancreatic cancer.American journal of translational research · 2020Article
- Single-cell murine genetic fate mapping reveals bipotential hepatoblasts and novel multi-organ endoderm progenitors.Development (Cambridge, England) · 2018Article
- Tetraspanins Function as Regulators of Cellular Signaling.Frontiers in cell and developmental biology · 2017Review
- Tetraspanin 8 mediates AEG-1-induced invasion and metastasis in hepatocellular carcinoma cells.FEBS letters · 2016Article
- Frogs as integrative models for understanding digestive organ development and evolution.Seminars in cell & developmental biology · 2016Review
- Xenopus as a Model for GI/Pancreas Disease.Current pathobiology reports · 2015Article
- Annular pancreas in Trichorhinophalangeal syndrome type II with 8q23.3-q24.12 interstitial deletion.Molecular cytogenetics · 2015Article
- Microarray analysis of Xenopus endoderm expressing Ptf1a.Genesis (New York, N.Y. : 2000) · 2012Article
- Development of Xenopus resource centers: the National Xenopus Resource and the European Xenopus Resource Center.Genesis (New York, N.Y. : 2000) · 2012Review
- Transient expression of Ngn3 in Xenopus endoderm promotes early and ectopic development of pancreatic beta and delta cells.Genesis (New York, N.Y. : 2000) · 2012Article
- Xenopus research: metamorphosed by genetics and genomics.Trends in genetics : TIG · 2011Review
- The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.Development (Cambridge, England) · 2011Article
- Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes.Developmental biology · 2011Article
- From genetic association to molecular mechanism.Current diabetes reports · 2010Review
- BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA.Developmental biology · 2010Article
- Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targets.Expert reviews in molecular medicine · 2010Review
- Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development.BMC developmental biology · 2009Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
During embryogenesis, the pancreas develops from separate dorsal and ventral buds, which fuse to form the mature pancreas. Little is known about the functional differences between these two buds or the relative contribution of cells derived from each region to the pancreas after fusion. To follow the fate of dorsal or ventral bud derived cells in the pancreas after fusion, we produced chimeric Elas-GFP transgenic/wild-type embryos in which either dorsal or ventral pancreatic bud cells expressed GFP. We found that ventral pancreatic cells migrate extensively into the dorsal pancreas after fusion, whereas the converse does not occur. Moreover, we found that annular pancreatic tissue is composed exclusively of ventral pancreas-derived cells. To identify ventral pancreas-specific genes that may play a role in pancreatic bud fusion, we isolated individual dorsal and ventral pancreatic buds, prior to fusion, from NF38/39 Xenopus laevis tadpoles and compared their gene expression profiles (NF refers to the specific stage of Xenopus development). As a result of this screen, we have identified several new ventral pancreas-specific genes, all of which are expressed in the same location within the ventral pancreas at the junction where the two ventral pancreatic buds fuse. Morpholino-mediated knockdown of one of these ventral-specific genes, transmembrane 4 superfamily member 3 (tm4sf3), inhibited dorsal-ventral pancreatic bud fusion, as well as acinar cell differentiation. Conversely, overexpression of tm4sf3 promoted development of annular pancreas. Our results are the first to define molecular and behavioral differences between the dorsal and ventral pancreas, and suggest an unexpected role for the ventral pancreas in pancreatic bud fusion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.