Trial reportThe American journal of clinical nutrition2009
Effects of selenomethionine supplementation on selenium status and thyroid hormone concentrations in healthy adults.
Trial report in The American journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 83 citations in OpenAlex.
- Intake of partially defatted Brazil nut flour reduces serum cholesterol in hypercholesterolemic patients--a randomized controlled trial.Nutrition journal · 2015Trial
- Trial
- Dietary selenium intake, hypertension and cognitive function among US adults, NHANES 2011-2014.Scientific reports · 2024Article
- Understanding the Roles of Selenium on Thyroid Hormone-Induced Thermogenesis in Adipose Tissue.Biological trace element research · 2024Review
- Association between dietary selenium intake and the prevalence of osteoporosis and its role in the treatment of glucocorticoid-induced osteoporosis.Journal of orthopaedic surgery and research · 2023Article
- Association between dietary selenium intake and bone mineral density in the US general population.Annals of translational medicine · 2022Article
- Review
- Associations between Urinary and Dietary Selenium and Blood Metabolic Parameters in a Healthy Northern Italy Population.Antioxidants (Basel, Switzerland) · 2021Article
- Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels.International journal of molecular sciences · 2021Review
- Inherited Disorders of Thyroid Hormone Metabolism Defect Caused by the Dysregulation of Selenoprotein Expression.Frontiers in endocrinology · 2021Review
- Higher Dietary Se Intake Is Associated With the Risk of New-Onset Fracture: A National Longitudinal Study for 20 Years.Frontiers in nutrition · 2021Article
- Selenium Kinetics in Humans Change Following 2 Years of Supplementation With Selenomethionine.Frontiers in endocrinology · 2021Article
- SEXUAL DIMORPHISM IN SELENIUM METABOLISM AND SELENOPROTEINS.Free radical biology & medicine · 2018Review
- Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study.Nutrients · 2018Observational
- High dietary selenium intake is associated with less insulin resistance in the Newfoundland population.PloS one · 2017Article
- Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants.International journal of molecular sciences · 2015Review
- Features of selenium metabolism in humans living under the conditions of North European Russia.International archives of occupational and environmental health · 2014Article
- Selenium supplementation in thyroid associated ophthalmopathy: an update.International journal of ophthalmology · 2014Review
- Sex-specific transcriptional responses of the zebrafish (Danio rerio) brain selenoproteome to acute sodium selenite supplementation.Physiological genomics · 2013Article
- Thyroid Hormones and Cortisol Concentrations in Offspring are Influenced by Maternal Supranutritional Selenium and Nutritional Plane in Sheep.Nutrition and metabolic insights · 2013Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSelenium, a potential cancer prevention agent currently being tested against prostate cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT), plays an integral role in thyroid metabolism. The effects of long-term selenium supplementation on thyroid hormone concentrations are unknown.
objectiveThe objective was to investigate the effects of long-term selenium supplementation on thyroid hormone concentrations.
designTwenty-eight healthy adults took 200 microg selenomethionine/d for 28 mo. The thyroid hormones triiodothyronine (T3), thyroxine (T4), and thyrotropin (TSH) were measured in plasma for 4 mo before supplementation and quarterly during supplementation. The assay methods were changed midstudy; the results of the 2 methods were not comparable. Therefore, one analysis was conducted based on the results of the first method, and a second analysis was based on all of the data, adjusted for the change. Serial data collection permitted a test for trends rather than simply a difference between initial and final values.
resultsBy 9 mo, mean (+/-SEM) plasma selenium concentrations had increased from 1.78 +/- 0.07 micromol/L at baseline to 2.85 +/- 0.11 micromol/L for men and from 1.64 +/- 0.04 to 3.32 +/- 0.1.2 micromol/L for women. T3 concentrations in men increased 5% per year (P = 0.01). T4 and TSH concentrations were unchanged.
conclusionsSelenium supplementation produced no clinically significant changes in thyroid hormone concentrations. A small but statistically significant increase in T3 concentrations was noted in men, with no corresponding decreases in TSH. A subset of SELECT subjects might be monitored periodically for changes during long-term selenium supplementation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.