ArticleThe Journal of physiology2009
Mechanisms underlying short-term modulation of transmitter release by presynaptic depolarization.
Article in The Journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part I: Principles of Electrical Neuromodulation and Adverse Effects.Bioelectromagnetics · 2025Review
- KGlia · 2022Article
- Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Frequency-Dependent Block of Excitatory Neurotransmission by Isoflurane via Dual Presynaptic Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Timing constraints of action potential evoked CaScientific reports · 2019Article
- Dynamic Factors for Transmitter Release at Small Presynaptic Boutons Revealed by Direct Patch-Clamp Recordings.Frontiers in cellular neuroscience · 2019Review
- Past and Future of Analog-Digital Modulation of Synaptic Transmission.Frontiers in cellular neuroscience · 2019Review
- Neuromodulation of Axon Terminals.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- NMDA receptor-dependent presynaptic inhibition at the calyx of Held synapse of rat pups.Open biology · 2017Article
- Ca(2+) current facilitation determines short-term facilitation at inhibitory synapses between cerebellar Purkinje cells.The Journal of physiology · 2015Article
- Transmembrane AMPAR regulatory protein γ-2 is required for the modulation of GABA release by presynaptic AMPARs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Ca2+ channel to synaptic vesicle distance accounts for the readily releasable pool kinetics at a functionally mature auditory synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Strength and precision of neurotransmission at mammalian presynaptic terminals.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2015Review
- Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Membrane properties of striatal direct and indirect pathway neurons in mouse and rat slices and their modulation by dopamine.PloS one · 2013Article
- Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Targeted axon-attached recording with fluorescent patch-clamp pipettes in brain slices.Nature protocols · 2012Article
- Effects of axonal topology on the somatic modulation of synaptic outputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Similar intracellular Ca2+ requirements for inactivation and facilitation of voltage-gated Ca2+ channels in a glutamatergic mammalian nerve terminal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Ionotropic receptors at hippocampal mossy fibers: roles in axonal excitability, synaptic transmission, and plasticity.Frontiers in neural circuits · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Presynaptic terminal depolarization modulates the efficacy of transmitter release. Residual Ca2+ remaining after presynaptic depolarization is thought to play a critical role in facilitation of transmitter release, but its downstream mechanism remains unclear. By making simultaneous pre- and postsynaptic recordings at the rodent calyx of Held synapse, we have investigated mechanisms involved in the facilitation and depression of postsynaptic currents induced by presynaptic depolarization. In voltage-clamp experiments, cancellation of the Ca2+-dependent presynaptic Ca2+ current (I(pCa)) facilitation revealed that this mechanism can account for 50% of postsynaptic current facilitation, irrespective of intraterminal EGTA concentrations. Intraterminal EGTA, loaded at 10 mM, failed to block postsynaptic current facilitation, but additional BAPTA at 1 mM abolished it. Potassium-induced sustained depolarization of non-dialysed presynaptic terminals caused a facilitation of postsynaptic currents, superimposed on a depression, with the latter resulting from reductions in presynaptic action potential amplitude and number of releasable vesicles. We conclude that presynaptic depolarization bidirectionally modulates transmitter release, and that the residual Ca2+ mechanism for synaptic facilitation operates in the immediate vicinity of voltage-gated Ca2+ channels in the nerve terminal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.