ArticleInternational journal of surgical pathology2011
Angiogenesis in the progression of breast ductal proliferations.
Article in International journal of surgical pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- High-speed photoacoustic and ultrasonic computed tomography of the breast tumor for early diagnosis with enhanced accuracy.Science advances · 2025Article
- Review
- The emerging role of photoacoustic imaging in clinical oncology.Nature reviews. Clinical oncology · 2022Review
- Propensity for Early Metastatic Spread in Breast Cancer: Role of Tumor Vascularization Features and Tumor Immune Infiltrate.Cancers · 2021Review
- Non-randomness of the anatomical distribution of tumors.Cancer convergence · 2017Article
- Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis.Breast cancer research : BCR · 2016Article
- Clinical Report on the First Prototype of a Photoacoustic Tomography System with Dual Illumination for Breast Cancer Imaging.PloS one · 2015Article
- Earlier detection of breast cancer with ultrasound molecular imaging in a transgenic mouse model.Cancer research · 2013Article
- Estimation of immunohistochemical expression of VEGF in ductal carcinomas of the breast.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Breast Tumor Angiogenesis and Tumor-Associated Macrophages: Histopathologist's Perspective.Pathology research international · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Angiogenesis, the formation of blood vessels, is necessary for a tumor to grow, but when angiogenesis first appears in the progression of breast ductal carcinomas is unknown. To determine when this occurs, the authors examined microvessel density (MVD) by CD31 and CD105 immunostaining in normal ducts, 32 cases of usual hyperplasia, 19 cases of atypical hyperplasia, and 29 cases of ductal carcinoma in situ (DCIS). Simple hyperplasia had a 22-fold greater MVD than normal ducts (P < .0001). An increase during the progression of ductal changes was highly significant (P < .0001). To determine a possible mechanism, immunohistochemistry for vascular endothelial growth factor (VEGF) was evaluated. VEGF staining intensity of ductal epithelium increased during the progression from normal to hyperplastic to DCIS. This study shows that the first significant increase in angiogenesis occurs very early in the evolution of ductal proliferations as ductal cells become hyperplastic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.