ArticleHuman genomics2009
A biophysical mechanism may control the collinearity of Hoxd genes during the early phase of limb development.
Article in Human genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 10 citations in OpenAlex.
- Physical Laws Shape Up HOX Gene Collinearity.Journal of developmental biology · 2021Review
- Article
- Evolutionary constraints favor a biophysical model explaining hox gene collinearity.Current genomics · 2013Article
- Comparison of models for the collinearity of hox genes in the developmental axes of vertebrates.Current genomics · 2012Article
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1 author at 1 institution in 1 country.
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Abstract
A biophysical model has been proposed which deals with the observed collinearity of Hox gene expressions in developing vertebrate limbs. It is assumed that physical forces gradually dislocate the genes of the Hoxd cluster from inside the chromosome territory into the interchromosome domain, where the genes are activated. In particular, the action of Coulomb electric forces has been estimated in detail. Genetic engineering experiments (deletions, duplications and transpositions) were recently reported for Hoxd expression during limb development. Here, we analyse these results and show that the biophysical model explains them successfully.
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