ReviewClinical immunology (Orlando, Fla.)2009
Breaking old paradigms: Th17 cells in autoimmune arthritis.
Review in Clinical immunology (Orlando, Fla.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed.
- Cyclooxygenase-2-Prostaglandin E2 pathway: A key player in tumor-associated immune cells.Frontiers in oncology · 2023Review
- Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism.Cellular & molecular biology letters · 2022Article
- Coadministration of Stigmasterol and Dexamethasone (STIG+DEX) Modulates Steroid-Resistant Asthma.Mediators of inflammation · 2022Article
- Soufeng sanjie formula alleviates collagen-induced arthritis in mice by inhibiting Th17 cell differentiation.Chinese medicine · 2021Article
- T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1/Th2/Th9/Th17/Th22/Tfh Cells.Frontiers in immunology · 2020Review
- Efficient Therapeutic Function and Mechanisms of Human Polyclonal CD8Journal of immunology research · 2019Article
- Is there a role for cherries in the management of gout?Therapeutic advances in musculoskeletal disease · 2019Review
- Crocin exerts anti-inflammatory and anti-arthritic effects on type II collagen-induced arthritis in rats.Pharmaceutical biology · 2018Article
- Interleukin-17A Plays the Same Role on Mice Acute Lung Injury Respectively Induced by Lipopolysaccharide and Paraquat.Inflammation · 2017Article
- Peripheral blood T helper type 17 frequency shows an inverse correlation with disease activity and magnetic resonance imaging-based osteitis and erosions in disease-modifying anti-rheumatic drug- and steroid-naive established rheumatoid arthritis.Clinical and experimental immunology · 2016Article
- Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis.Molecular medicine reports · 2016Article
- Dietary extra-virgin olive oil prevents inflammatory response and cartilage matrix degradation in murine collagen-induced arthritis.European journal of nutrition · 2016Article
- Reduced levels of T-helper 17-associated cytokines in the serum of patients with breast cancer: indicators for following the course of disease.Central-European journal of immunology · 2016Article
- Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis.PloS one · 2016Article
- CXCL13 antibody for the treatment of autoimmune disorders.BMC immunology · 2015Article
- Increased interleukin-17 transcripts in peripheral blood mononuclear cells, a link between T-helper 17 and proinflammatory responses in bladder cancer.Iranian Red Crescent medical journal · 2015Article
- Article
- Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?Arthritis research & therapy · 2014Article
- The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis.Arthritis research & therapy · 2014Article
- Insulin resistance and serum levels of interleukin-17 and interleukin-18 in normal pregnancy.Immune network · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Aberrant helper T cell activation has been implicated in the pathogenesis of an array of autoimmune diseases. In this review, we summarize evidence that suggests the involvement of a novel T cell subset, the Th17 lineage, in rheumatoid arthritis. In particular, we focus on the role of Th17 cells in inducing and perpetuating the chronic inflammation, cartilage damage, and bone erosion that are hallmark phases of joint destruction and consider current and emerging therapies that seek to disrupt the inflammatory Th17 network and shift the immune system back towards homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.