ArticleEmerging infectious diseases2009
Chloroquine-resistant haplotype Plasmodium falciparum parasites, Haiti.
Article in Emerging infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Access and coverage of malaria services in Haiti in the context of elimination: a scoping review of the literature.BMC health services research · 2024Article
- Population Genomic Evidence of Adaptive Response during the Invasion History of Plasmodium falciparum in the Americas.Molecular biology and evolution · 2023Article
- Assessment of Plasmodium falciparum anti-malarial drug resistance markers in pfcrt and pfmdr1 genes in isolates from Honduras and Nicaragua, 2018-2021.Malaria journal · 2021Article
- Establishing a National Molecular Surveillance Program for the Detection ofThe American journal of tropical medicine and hygiene · 2020Article
- Article
- Nationwide Monitoring for Plasmodium falciparum Drug-Resistance Alleles to Chloroquine, Sulfadoxine, and Pyrimethamine, Haiti, 2016-2017.Emerging infectious diseases · 2020Article
- No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti.Emerging infectious diseases · 2018Article
- "Wherever doctors cannot reach, the sunshine can": overcoming potential barriers to malaria elimination interventions in Haiti.Malaria journal · 2018Article
- Malaria Surveillance - United States, 2015.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2018Article
- Haiti's Commitment to Malaria Elimination: Progress in the Face of Challenges, 2010-2016.The American journal of tropical medicine and hygiene · 2017Article
- In vivo study of Plasmodium falciparum chloroquine susceptibility in three departments of Haiti.Malaria journal · 2017Article
- Malaria Surveillance - United States, 2014.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2017Article
- Plasmodium falciparum Drug-Resistant Haplotypes and Population Structure in Postearthquake Haiti, 2010.The American journal of tropical medicine and hygiene · 2016Article
- Plasmodium falciparum K76T pfcrt Gene Mutations and Parasite Population Structure, Haiti, 2006-2009.Emerging infectious diseases · 2016Article
- Malaria elimination in Haiti by the year 2020: an achievable goal?Malaria journal · 2015Article
- Therapeutic efficacy of chloroquine for the treatment of uncomplicated Plasmodium falciparum in Haiti after many decades of its use.The American journal of tropical medicine and hygiene · 2015Article
- Genetic Diversity of Plasmodium falciparum in Haiti: Insights from Microsatellite Markers.PloS one · 2015Article
- Age-specific malaria seroprevalence rates: a cross-sectional analysis of malaria transmission in the Ouest and Sud-Est departments of Haiti.Malaria journal · 2014Article
- Molecular analysis of chloroquine and sulfadoxine-pyrimethamine resistance-associated alleles in Plasmodium falciparum isolates from Nicaragua.The American journal of tropical medicine and hygiene · 2014Article
- Challenges of drug-resistant malaria.Parasite (Paris, France) · 2014Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmodium falciparum parasites have been endemic to Haiti for >40 years without evidence of chloroquine (CQ) resistance. In 2006 and 2007, we obtained blood smears for rapid diagnostic tests (RDTs) and filter paper blots of blood from 821 persons by passive and active case detection. P. falciparum infections diagnosed for 79 persons by blood smear or RDT were confirmed by PCR for the small subunit rRNA gene of P. falciparum. Amplification of the P. falciparum CQ resistance transporter (pfcrt) gene yielded 10 samples with amplicons resistant to cleavage by ApoI. A total of 5 of 9 samples had threonine at position 76 of pfcrt, which is consistent with CQ resistance (haplotypes at positions 72-76 were CVIET [n = 4] and CVMNT [n = 1]); 4 had only the wild-type haplotype associated with CQ susceptibility (CVMNK). These results indicate that CQ-resistant haplotype P. falciparum malaria parasites are present in Haiti.
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