ArticleLipids in health and disease2009
Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes.
Article in Lipids in health and disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Conjugated linoleic acid and glucosamine supplements may prevent bone loss in aging by regulating the RANKL/RANK/OPG pathway.Molecular biology reports · 2023Review
- In Silico Network Analysis of Ingredients of Cornus officinalis in Osteoporosis.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- The effect of conjugated linoleic acid on oxidative stress and matrix metalloproteinases 2 and 9 in patients with COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- Article
- Conjugated linoleic acid and calcium co-supplementation improves bone health in ovariectomised mice.Food chemistry · 2013Article
- trans-10,cis-12 conjugated linoleic acid promotes bone formation by inhibiting adipogenesis by peroxisome proliferator activated receptor-γ-dependent mechanisms and by directly enhancing osteoblastogenesis from bone marrow mesenchymal stem cells.The Journal of nutritional biochemistry · 2013Article
- t10c12-CLA maintains higher bone mineral density during aging by modulating osteoclastogenesis and bone marrow adiposity.Journal of cellular physiology · 2011Article
- Interaction between dietary conjugated linoleic acid and calcium supplementation affecting bone and fat mass.Journal of bone and mineral metabolism · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMixed CLA isomers variably affect bone resorption in animals and decrease osteoclast formation and activity in murine osteoclasts. These variable effects may be due to the different isomers present in commercial preparations of CLA, and the effects of the predominant individual isomers, 9cis,11trans (9,11) and 10trans,12cis (10,12) CLA are not clear. The objectives of this study were to determine the effects of the individual CLA isomers on osteoclast formation and activity from human CD14+ monocytes, and to determine whether any changes are accompanied by changes in cathepsin K, matrix metalloproteinase-9 (MMP-9), receptor activator of NF-kappaB (RANK) and tumour necrosis factor alpha (TNFalpha) gene expression. Osteoclasts were identified as TRAP+ multinucleated cells. Osteoclast activity was quantified by the amount of TRAP in the cultured media.
resultsAt 50 microM, 9,11 CLA inhibited osteoclast formation by approximately 70%, and both 9,11 and 10,12 CLA decreased osteoclast activity by approximately 85-90%. Both isomers inhibited cathepsin K (50 microM 9,11 by approximately 60%; 10,12 by approximately 50%) and RANK (50 microM 9,11 by approximately 85%; 50 microM 10,12 by approximately 65%) expression, but had no effect on MMP-9 or TNFalpha expression.
conclusion9,11 CLA inhibits osteoclast formation and activity from human cells, suggesting that this isomer may prevent bone resorption in humans. Although 10,12 CLA did not significantly reduce osteoclast formation, it reduced osteoclast activity and cathepsin K and RANK expression, suggesting that this isomer may also affect bone resorption.
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