ArticlePLoS biology2009
Accelerated adaptive evolution on a newly formed X chromosome.
Article in PLoS biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 65 citations in OpenAlex.
- Inferring the Relative Contributions of Evolutionary Processes Shaping X Chromosome Dynamics in the Common Marmoset (Callithrix jacchus) in the Presence of Twinning and Hematopoietic Chimerism.Genome biology and evolution · 2026Article
- Recent Insights Into the Evolutionary Genomics of the Critically Endangered Aye-Aye (Daubentonia madagascariensis).American journal of primatology · 2025Review
- Interpreting Patterns of X Chromosomal Relative to Autosomal Diversity in Aye-Ayes (Daubentonia madagascariensis).American journal of primatology · 2025Article
- Positive Selection Drives cis-regulatory Evolution Across the Threespine Stickleback Y Chromosome.Molecular biology and evolution · 2024Article
- Moths passing in the night: Phenological and genomic divergences within a forest pest complex.Evolutionary applications · 2022Article
- Evolution of CDK1 Paralog Specializations in a Lineage With Fast Developing Planktonic Embryos.Frontiers in cell and developmental biology · 2021Article
- The Y Chromosome as a Battleground for Intragenomic Conflict.Trends in genetics : TIG · 2020Review
- The Formation of Sex Chromosomes inFrontiers in plant science · 2020Article
- Insights into the Structure of the Spruce Budworm (G3 (Bethesda, Md.) · 2018Article
- Rapid neo-sex chromosome evolution and incipient speciation in a major forest pest.Nature communications · 2017Article
- Neo-sex Chromosomes in the Monarch Butterfly,G3 (Bethesda, Md.) · 2017Article
- Extremely low nucleotide diversity in the X-linked region of papaya caused by a strong selective sweep.Genome biology · 2016Article
- Article
- Faster-X effects in two Drosophila lineages.Genome biology and evolution · 2014Article
- Anolis sex chromosomes are derived from a single ancestral pair.Evolution; international journal of organic evolution · 2014Article
- Sex chromosome turnover contributes to genomic divergence between incipient stickleback species.PLoS genetics · 2014Article
- Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans.BMC genomics · 2012Article
- Extensive X-linked adaptive evolution in central chimpanzees.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- The sex-specific region of sex chromosomes in animals and plants.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- An excess of gene expression divergence on the X chromosome in Drosophila embryos: implications for the faster-X hypothesis.PLoS genetics · 2012Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Sex chromosomes originated from ordinary autosomes, and their evolution is characterized by continuous gene loss from the ancestral Y chromosome. Here, we document a new feature of sex chromosome evolution: bursts of adaptive fixations on a newly formed X chromosome. Taking advantage of the recently formed neo-X chromosome of Drosophila miranda, we compare patterns of DNA sequence variation at genes located on the neo-X to genes on the ancestral X chromosome. This contrast allows us to draw inferences of selection on a newly formed X chromosome relative to background levels of adaptation in the genome while controlling for demographic effects. Chromosome-wide synonymous diversity on the neo-X is reduced 2-fold relative to the ancestral X, as expected under recent and recurrent directional selection. Several statistical tests employing various features of the data consistently identify 10%-15% of neo-X genes as targets of recent adaptive evolution but only 1%-3% of genes on the ancestral X. In addition, both the rate of adaptation and the fitness effects of adaptive substitutions are estimated to be roughly an order of magnitude higher for neo-X genes relative to genes on the ancestral X. Thus, newly formed X chromosomes are not passive players in the evolutionary process of sex chromosome differentiation, but respond adaptively to both their sex-biased transmission and to Y chromosome degeneration, possibly through demasculinization of their gene content and the evolution of dosage compensation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.