ArticlePloS one2009
Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 84 citations in OpenAlex.
- Review
- Lifespan and ROS levels in different Drosophila melanogaster strains after 24 h hypoxia exposure.Biology open · 2022Article
- Phylogenetic annotation ofmicroPublication biology · 2022Article
- Hypoxia Tolerant Species: The Wisdom of Nature Translated into Targets for Stroke Therapy.International journal of molecular sciences · 2021Review
- Multiple mechanisms drive genomic adaptation to extreme ONature communications · 2021Article
- Lisinopril Preserves Physical Resilience and Extends Life Span in a Genotype-Specific Manner in Drosophila melanogaster.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Altering social cue perception impacts honey bee aggression with minimal impacts on aggression-related brain gene expression.Scientific reports · 2019Article
- Genome-Wide Association Analysis of Anoxia Tolerance inG3 (Bethesda, Md.) · 2019Article
- Role of Modified Atmosphere in Pest Control and Mechanism of Its Effect on Insects.Frontiers in physiology · 2019Review
- RNA-Sequencing ofG3 (Bethesda, Md.) · 2018Article
- Transcriptomic analysis identifies a role of PI3K-Akt signalling in the responses of skeletal muscle to acute hypoxia in vivo.The Journal of physiology · 2017Article
- A genetically encoded biosensor for visualising hypoxia responsesBiology open · 2017Article
- Head Transcriptomes of Two Closely Related Species of Fruit Flies of the Anastrepha fraterculus Group Reveals Divergent Genes in Species with Extensive Gene Flow.G3 (Bethesda, Md.) · 2016Article
- Brazilian Pampa Biome Honey Protects Against Mortality, Locomotor Deficits and Oxidative Stress Induced by Hypoxia/Reperfusion in Adult Drosophila melanogaster.Neurochemical research · 2016Article
- Dynamic changes in host-virus interactions associated with colony founding and social environment in fire ant queens (Solenopsis invicta).Ecology and evolution · 2016Article
- Do the genes of the innate immune response contribute to neuroprotection in Drosophila?Journal of innate immunity · 2015Review
- Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster.Bioscience reports · 2014Article
- MAAMD: a workflow to standardize meta-analyses and comparison of affymetrix microarray data.BMC bioinformatics · 2014Article
- Transcriptome-based identification of ABC transporters in the western tarnished plant bug Lygus hesperus.PloS one · 2014Article
- Manipulation of colony environment modulates honey bee aggression and brain gene expression.Genes, brain, and behavior · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundConstant hypoxia (CH) and intermittent hypoxia (IH) occur during several pathological conditions such as asthma and obstructive sleep apnea. Our research is focused on understanding the molecular mechanisms that lead to injury or adaptation to hypoxic stress using Drosophila as a model system. Our current genome-wide study is designed to investigate gene expression changes and identify protective mechanism(s) in D. melanogaster after exposure to severe (1% O(2)) intermittent or constant hypoxia. METHODOLOGY/PRINCIPAL
findingsOur microarray analysis has identified multiple gene families that are up- or down-regulated in response to acute CH or IH. We observed distinct responses to IH and CH in gene expression that varied in the number of genes and type of gene families. We then studied the role of candidate genes (up-or down-regulated) in hypoxia tolerance (adult survival) for longer periods (CH-7 days, IH-10 days) under severe CH or IH. Heat shock proteins up-regulation (specifically Hsp23 and Hsp70) led to a significant increase in adult survival (as compared to controls) of P-element lines during CH. In contrast, during IH treatment the up-regulation of Mdr49 and l(2)08717 genes (P-element lines) provided survival advantage over controls. This suggests that the increased transcript levels following treatment with either paradigm play an important role in tolerance to severe hypoxia. Furthermore, by over-expressing Hsp70 in specific tissues, we found that up-regulation of Hsp70 in heart and brain play critical role in tolerance to CH in flies. CONCLUSIONS/SIGNIFICANCE: We observed that the gene expression response to IH or CH is specific and paradigm-dependent. We have identified several genes Hsp23, Hsp70, CG1600, l(2)08717 and Mdr49 that play an important role in hypoxia tolerance whether it is in CH or IH. These data provide further clues about the mechanisms by which IH or CH lead to cell injury and morbidity or adaptation and survival.
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