ArticleThe Journal of biological chemistry2009
Loss of cardiolipin leads to longevity defects that are alleviated by alterations in stress response signaling.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Setting the curve: the biophysical properties of lipids in mitochondrial form and function.Journal of lipid research · 2024Review
- Hog1 acts in a Mec1-independent manner to counteract oxidative stress following telomerase inactivation in Saccharomyces cerevisiae.Communications biology · 2024Article
- Lifespan Extension ofInternational journal of molecular sciences · 2022Article
- The Crucial Roles of Phospholipids in Aging and Lifespan Regulation.Frontiers in physiology · 2021Review
- Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2018Article
- Cardiolipin deficiency causes triacylglycerol accumulation in Saccharomyces cerevisiae.Molecular and cellular biochemistry · 2017Article
- Non-linear actions of physiological agents: Finite disarrangements elicit fitness benefits.Redox biology · 2017Review
- Cardiolipin Regulates Mitophagy through the Protein Kinase C Pathway.The Journal of biological chemistry · 2017Article
- Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells.ACS chemical biology · 2017Article
- Role of Cardiolipin in Mitochondrial Signaling Pathways.Frontiers in cell and developmental biology · 2017Review
- Get1p and Get2p are required for maintenance of mitochondrial morphology and normal cardiolipin levels.FEMS yeast research · 2016Article
- The Role of Cardiolipin in Cardiovascular Health.BioMed research international · 2015Review
- The functions of cardiolipin in cellular metabolism-potential modifiers of the Barth syndrome phenotype.Chemistry and physics of lipids · 2014Review
- Making heads or tails of mitochondrial membranes in longevity and aging: a role for comparative studies.Longevity & healthspan · 2014Article
- Deletion of the cardiolipin-specific phospholipase Cld1 rescues growth and life span defects in the tafazzin mutant: implications for Barth syndrome.The Journal of biological chemistry · 2014Article
- The retrograde response: a conserved compensatory reaction to damage from within and from without.Progress in molecular biology and translational science · 2014Review
- Cardiolipin and mitochondrial phosphatidylethanolamine have overlapping functions in mitochondrial fusion in Saccharomyces cerevisiae.The Journal of biological chemistry · 2012Article
- Macromolecules that prefer their membranes curvy.Molecular microbiology · 2010Review
- Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction.The Journal of biological chemistry · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Perturbation of cardiolipin (CL) synthesis in yeast cells leads to defective respiratory chain function and mitochondrial DNA loss, both of which have been implicated in aging in mammals. The availability of yeast CL mutants enabled us to directly investigate the role of CL synthesis in aging. In this report, we show that the replicative life span of pgs1Delta, which lacks both CL and the precursor phosphatidylglycerol (PG), was significantly decreased at 30 degrees C. The life span of crd1Delta, which has PG but not CL, was unaffected at 30 degrees C but reduced at 37 degrees C. Life span extension induced by calorie restriction was not affected by the loss of CL. However, mild heat and osmotic stress, which extend life span in wild type cells, did not increase longevity in CL mutants, suggesting that the stress response is perturbed in these mutants. Consistent with this, longevity defects in pgs1Delta were alleviated by down-regulation of the high osmolarity glycerol stress response pathway, as well as by promoting cell integrity with the osmotic stabilizer sorbitol or via genetic suppression with the kre5(W1166X) mutant. These findings show for the first time that perturbation of CL synthesis leads to decreased longevity in yeast, which is restored by altering signaling through stress response pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.