Trial reportAmerican journal of physiology. Endocrinology and metabolism2009
Menstrual cycle alters sympathetic neural responses to orthostatic stress in young, eumenorrheic women.
Trial report in American journal of physiology. Endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 84 citations in OpenAlex.
- Effect of oral hormonal contraceptive pill use on the hemodynamic response to the cold pressor test.American journal of physiology. Heart and circulatory physiology · 2022Trial
- Hyperoxia Improves Hemodynamic Status During Head-up Tilt Testing in Healthy Volunteers: A Randomized Study.Medicine · 2016Trial
- Role of the ovarian cycle on neural cardiovascular control in sleep-deprived women.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Attenuation of sympathetic baroreflex sensitivity during the onset of acute mental stress in humans.American journal of physiology. Heart and circulatory physiology · 2011Trial
- Influence of acute alcohol ingestion on sympathetic neural responses to orthostatic stress in humans.American journal of physiology. Endocrinology and metabolism · 2011Trial
- Effects of oral contraceptives on sympathetic nerve activity during orthostatic stress in young, healthy women.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Trial
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Partial reduction of parasympathetic nerve activity during sleep after endurance exercise under hypoxic conditions.Physical activity and nutrition · 2025Article
- Influence of sex on sympathetic vasomotor outflow responses to passive leg raising in young individuals.The journal of physiological sciences : JPS · 2024Article
- Additive influence of exercise pressor reflex activation on Valsalva responses in white and black adults.European journal of applied physiology · 2023Article
- Posture-related changes in sympathetic baroreflex sensitivity during normal pregnancy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Cerebral autoregulation across the menstrual cycle in eumenorrheic women.Physiological reports · 2022Article
- The Specificities of Elite Female Athletes: A Multidisciplinary Approach.Life (Basel, Switzerland) · 2021Review
- CORP: Standardizing methodology for assessing spontaneous baroreflex control of muscle sympathetic nerve activity in humans.American journal of physiology. Heart and circulatory physiology · 2021Article
- Comparison of high-fat style diet-induced dysregulation of baroreflex control of renal sympathetic nerve activity in intact and ovariectomized female rats: Renal sympathetic nerve activity in high-fat style diet fed intact and ovariectomized female rats.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- When Sinus Tachycardia Becomes Too Much: Negative Effects of Excessive Upright Tachycardia on Cardiac Output in Vasovagal Syncope, Postural Tachycardia Syndrome, and Inappropriate Sinus Tachycardia.Circulation. Arrhythmia and electrophysiology · 2020Article
- Temperature regulation in women: Effects of the menstrual cycle.Temperature (Austin, Tex.) · 2020Review
- Sex differences in baroreflex function in health and disease.The journal of physiological sciences : JPS · 2019Review
- Hydration Status and Cardiovascular Function.Nutrients · 2019Review
- Sympathetic neural responsiveness to sleep deprivation in older adults: sex differences.American journal of physiology. Heart and circulatory physiology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sympathetic baroreflex sensitivity (BRS) and muscle sympathetic nerve activity (MSNA) responses during early follicular (EF) and midluteal (ML) phases of the menstrual cycle are controversial. We hypothesize an augmented sympathetic BRS and MSNA response to orthostatic stress during the ML phase of the menstrual cycle. MSNA, mean arterial pressure (MAP), and heart rate (HR) were recorded during progressive lower body negative pressure (LBNP) (-5, -10, -15, -20, -30, and -40 mmHg; 3 min/stage) in 13 healthy, eumenorrheic women (age 21 +/- 1 yr). Sympathetic BRS was assessed by examining relations between spontaneous fluctuations of diastolic arterial pressure and MSNA at rest and during progressive LBNP. Plasma estradiol (42 +/- 6 vs. 112 +/- 12 pg/ml; P < 0.01) and progesterone (2 +/- 0 vs. 10 +/- 2 ng/ml; P < 0.04) were elevated during the ML phase. Resting MSNA (8 +/- 1 vs. 11 +/- 1 bursts/min), MAP (79 +/- 2 vs. 78 +/- 2 mmHg), and HR (58 +/- 2 vs. 60 +/- 2 beats/min) were not different during EF and ML phases. MSNA and HR increased during progressive LBNP (P < 0.001), and the increases in MSNA burst frequency (bursts/min) and HR were similar during both phases. In contrast, increases in total MSNA (arbitrary units) during progressive LBNP were augmented during the ML phase (P < 0.04), but this response does not appear to be linked to differences in sympathetic BRS. Progressive LBNP did not change MAP during either phase. Our results demonstrate an augmentation of the MSNA response to progressive LBNP during the ML phase of the menstrual cycle. These findings suggest that hormonal fluctuations of eumenorrheic women may influence sympathoexcitation during an orthostatic challenge, but not through sympathetic baroreflex-mediated pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.