Evidence map›Paper›PMID 19401302›Full record

ArticleCardiovascular research2009

Role of B-type natriuretic peptide in epoxyeicosatrienoic acid-mediated improved post-ischaemic recovery of heart contractile function.

Ketul R Chaudhary, Sri Nagarjun Batchu, Dipankar Das, Mavanur R Suresh, John R Falck, Joan P Graves, Darryl C Zeldin, John M Seubert

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  9. Article
  10. Epoxyeicosatrienoic acids and cardioprotection: the road to translation.Journal of molecular and cellular cardiology · 2014
    Review
  11. Article
  12. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats.American journal of physiology. Heart and circulatory physiology · 2012
    Article
  13. Article
  14. Review
  15. Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011
    Article
  16. Article
  17. Review
  18. Review
  19. Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.American journal of physiology. Heart and circulatory physiology · 2010
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ketul R ChaudharyFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada T6G 2N8.
Sri Nagarjun Batchu
Dipankar Das
Mavanur R Suresh
John R Falck
Joan P Graves
Darryl C Zeldin
John M Seubert
University of Alberta · CAResearch Triangle Park Foundation · USThe University of Texas Southwestern Medical Center · US

Funding

Characterization And Functional Significance Of P450 Arachidonate EpoxygenasesZIAES025034 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 2009 to 2025
$18.6M
Novel Eicosanoids: Synthesis and FunctionR01GM031278 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI FALCK, JOHN R. · 1985 to 2012
$4.7M
P450 Arachidonate EpoxygenasesZ01ES025034 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 1995 to 2008
$2.2M
Intramural NIH HHSNIEHS NIH HHS Z01 ES025034NIGMS NIH HHS GM31278
6 · The paper itself

Abstract

aimsThis study examined the functional role of B-type natriuretic peptide (BNP) in epoxyeicosatrienoic acid (EET)-mediated cardioprotection in mice with targeted disruption of the sEH or Ephx2 gene (sEH null). METHODS AND

resultsIsolated mouse hearts were perfused in the Langendorff mode and subjected to global no-flow ischaemia followed by reperfusion. Hearts were analysed for recovery of left ventricular developed pressure (LVDP), mRNA levels, and protein expression. Naïve hearts from sEH null mice had similar expression of preproBNP (Nppb) mRNA compared with wild-type (WT) hearts. However, significant increases in Nppb mRNA and BNP protein expression occurred during post-ischaemic reperfusion and correlated with improved post-ischaemic recovery of LVDP. Perfusion with the putative EET receptor antagonist 14,15-epoxyeicosa-5(Z)-enoic acid prior to ischaemia reduced the preproBNP mRNA in sEH null hearts. Inhibitor studies demonstrated that perfusion with the natriuretic peptide receptor type-A (NPR-A) antagonist, A71915, limited the improved recovery in recombinant full-length mouse BNP (rBNP)- and 11,12-EET-perfused hearts as well as in sEH null mice. Increased expression of phosphorylated protein kinase C epsilon and Akt were found in WT hearts perfused with either 11,12-EET or rBNP, while mitochondrial glycogen synthase kinase-3beta was significantly lower in the same samples. Furthermore, treatment with the phosphoinositide 3-kinase (PI3K) inhibitor wortmannin abolished improved LVDP recovery in 11,12-EET-treated hearts but not did significantly inhibit recovery of rBNP-treated hearts.

conclusionTaken together, these data indicate that EET-mediated cardioprotection involves BNP and PI3K signalling events.

Indexed as

Myocardial Contraction8,11,14-Eicosatrienoic AcidAnimalsAtrial Natriuretic FactorChromonesEpoxide HydrolasesFemaleGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaMaleMiceMice, Inbred C57BLMice, KnockoutMitochondria, HeartMorpholinesMyocardial Reperfusion Injury11,12-epoxy-5,8,14-eicosatrienoic acid14,15-eicosa-5-enoic acid2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one8,11,14-Eicosatrienoic AcidA 71915Atrial Natriuretic Factoratrial natriuretic factor receptor AChromonesEphx2 protein, mouseEpoxide HydrolasesGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaGsk3b protein, mouseMorpholinesNatriuretic Peptide, BrainNerve Tissue ProteinsPeptide FragmentsPhosphatidylinositol 3-Kinasesprepro-brain natriuretic peptidePrkce protein, mouseProtein Kinase C-epsilonProtein Kinase InhibitorsProtein PrecursorsProto-Oncogene Proteins c-aktReceptors, Atrial Natriuretic FactorRecombinant ProteinsRNA, MessengerTetrahydroisoquinolines

Identifiers

PMID19401302
PMCPMC2701722
OpenAlexW2095977665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.