ArticleNeuroscience2009
A role for dopamine D2 receptors in reversal learning.
Article in Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 61 citations in OpenAlex.
- Valence-Driven Cognitive Flexibility: Neurochemical and Circuit-Level Insights from Animal Models and Their Relevance to Schizophrenia.Biomolecules · 2025Review
- Alcohol, flexible behavior, and the prefrontal cortex: Functional changes underlying impaired cognitive flexibility.Neuropharmacology · 2024Review
- Article
- Nucleus Accumbens Core Dopamine D2 Receptor-Expressing Neurons Control Reversal Learning but Not Set-Shifting in Behavioral Flexibility in Male Mice.Frontiers in neuroscience · 2022Article
- Dopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila.Nature communications · 2021Article
- The relationship between monoaminergic gene expression, learning, and optimism in red junglefowl chicks.Animal cognition · 2020Article
- D2 receptors and cognitive flexibility in marmosets: tri-phasic dose-response effects of intra-striatal quinpirole on serial reversal performance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder.Brain and behavior · 2018Article
- The neural basis of reversal learning: An updated perspective.Neuroscience · 2017Review
- Adolescent Corticosterone and TrkB Pharmaco-Manipulations Sex-Dependently Impact Instrumental Reversal Learning Later in Life.Frontiers in behavioral neuroscience · 2017Article
- Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Multilevel developmental approaches to understanding the effects of child maltreatment: Recent advances and future challenges.Development and psychopathology · 2015Review
- Developmental psychopathology: recent advances and future challenges.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2015Article
- Synaptic Cytoskeletal Plasticity in the Prefrontal Cortex Following Psychostimulant Exposure.Traffic (Copenhagen, Denmark) · 2015Review
- Specific contributions of N-methyl-D-aspartate receptors in the dorsal striatum to cognitive flexibility.Neuroscience · 2015Article
- Ongoing behavioral state information signaled in the lateral habenula guides choice flexibility in freely moving rats.Frontiers in behavioral neuroscience · 2015Article
- Risperidone and the 5-HT2A receptor antagonist M100907 improve probabilistic reversal learning in BTBR T + tf/J mice.Autism research : official journal of the International Society for Autism Research · 2014Article
- Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia.Neuropharmacology · 2014Article
- Performance of C57BL/6J and DBA/2J mice on a touchscreen-based attentional set-shifting task.Behavioural brain research · 2014Article
- A novel role for brain interleukin-6: facilitation of cognitive flexibility in rat orbitofrontal cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Reversal learning has been shown to require intact serotonergic innervation of the forebrain neocortex. Whether dopamine acting through D2 receptors plays a complementary role in this anatomic area is still unclear. Here we show that mice lacking dopamine D2 receptors exhibited significantly impaired performance in the reversal learning phase of an attention-set-shifting task (ASST) and that wild type mice treated chronically with the D2-like receptor antagonist haloperidol exhibited the same cognitive deficit. The test-phase-specific deficits of D2 mutants and haloperidol-treated mice were also accompanied by deficits in the induction of expression of early growth response gene 2 (egr-2), a regulatory transcription factor previously shown to be selectively induced in the ventrolateral orbital frontal cortex and the pre- and infralimbic medial prefrontal cortex of ASST-tested mice. D2-receptor knockout mice and haloperidol-treated wild type, however, exhibited lower egr-2 expression in these anatomic regions after completion of an ASST-test phase that required reversal learning but not after completion of set-shifting phases without rule reversals. In contrast, mice treated chronically with clozapine, an atypical neuroleptic drug with lower D2-receptor affinity and broader pharmacological effects, had deficits in compound discrimination phases of the ASST, but also these deficits were accompanied by lower egr-2 expression in the same anatomic subregions. Thus, the findings indicate that egr-2 expression is a sensitive indicator of test-phase-specific performance in the ASST and that normal function of D2 receptors in subregions of the orbital frontal and the medial prefrontal cortex is required for cognitive flexibility in tests involving rule reversals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.