Evidence map›Paper›PMID 19401215›Full record

ArticleNeuroscience2009

Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human.

A G Bagó, E Dimitrov, R Saunders, L Seress, M Palkovits, T B Usdin, A Dobolyi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

A G BagóNeuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Histology and Endocrinology, Semmelweis University and the Hungarian Academy of Sciences, Tüzoltó u. 58, Budapest H-1094, Hungary.
E Dimitrov
R Saunders
L Seress
M Palkovits
T B Usdin
A Dobolyi
National Institute of Mental Health · USSemmelweis University · HUUniversity of Pecs · HU

Funding

Peptide Receptor SystemsZIAMH002685 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI USDIN, TED B · 2009 to 2016
$10.0M
SECRETIN/VIP FAMILY RECEPTORSZ01MH002685 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI USDIN, TED B · 1994 to 2008
$3.1M
Intramural NIH HHS Z01 MH002685
6 · The paper itself

Abstract

Parathyroid hormone receptor 2 (PTH2R) and its ligand, tuberoinfundibular peptide of 39 residues (TIP39) constitute a neuromodulator system implicated in endocrine and nociceptive regulation. We now describe the presence and distribution of the PTH2R and TIP39 in the brain of primates using a range of tissues and ages from macaque and human brain. In situ hybridization histochemistry of TIP39 mRNA, studied in young macaque brain, due to its possible decline beyond late postnatal ages, was present only in the thalamic subparafascicular area and the pontine medial paralemniscal nucleus. In contrast, in situ hybridization histochemistry in macaque identified high levels of PTH2R expression in the central amygdaloid nucleus, medial preoptic area, hypothalamic paraventricular and periventricular nuclei, medial geniculate, and the pontine tegmentum. PTH2R mRNA was also detected in several human brain areas by RT-PCR. The distribution of PTH2R-immunoreactive fibers in human, determined by immunocytochemistry, was similar to that in rodents, including dense fiber networks in the medial preoptic area, hypothalamic paraventricular, periventricular and infundibular (arcuate) nuclei, lateral hypothalamic area, median eminence, thalamic paraventricular nucleus, periaqueductal gray, lateral parabrachial nucleus, nucleus of the solitary tract, sensory trigeminal nuclei, medullary dorsal reticular nucleus, and dorsal horn of the spinal cord. Co-localization suggested that PTH2R fibers are glutamatergic, and that TIP39 may directly influence hypophysiotropic somatostatin containing and indirectly influence corticotropin releasing-hormone containing neurons. The results demonstrate that TIP39 and the PTH2R are expressed in the brain of primates in locations that suggest involvement in regulation of fear, anxiety, reproductive behaviors, release of pituitary hormones, and nociception.

Indexed as

Aged, 80 and overAgingAnimalsAnimals, NewbornBrainChildCorticotropin-Releasing HormoneFemaleHumansMacaca mulattaMaleMiddle AgedNeuronsNeuropeptidesReceptor, Parathyroid Hormone, Type 2SomatostatinCorticotropin-Releasing HormoneNeuropeptidesReceptor, Parathyroid Hormone, Type 2Somatostatintuberoinfundibular peptide 39Vesicular Glutamate Transport Protein 2

Identifiers

PMID19401215
PMCPMC2703999
OpenAlexW2044995747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.