ArticleThe international journal of neuropsychopharmacology2009
Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients.
Article in The international journal of neuropsychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Genes and gene networks implicated in aggression related behaviour.Neurogenetics · 2014Article
- Overexpression of diacylglycerol kinase η enhances Gαq-coupled G protein-coupled receptor signaling.Molecular pharmacology · 2014Article
- An evo-devo approach to thyroid hormones in cerebral and cerebellar cortical development: etiological implications for autism.Frontiers in endocrinology · 2014Review
- Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans.Brain research bulletin · 2012Review
- Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth.Molecular cancer research : MCR · 2012Article
- Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients.Molecular psychiatry · 2011Article
- Disturbed neurotransmitter transporter expression in Alzheimer's disease brain.Journal of Alzheimer's disease : JAD · 2011Article
- Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients.Molecular psychiatry · 2010Article
- Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients.Neurobiology of disease · 2010Article
- Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients.Journal of psychiatric research · 2010Article
- Brain lipid concentrations in bipolar disorder.Journal of psychiatric research · 2010Article
- Bipolar disorder and mechanisms of action of mood stabilizers.Brain research reviews · 2009Review
Corrections and comments
- Retraction · 2016-10-25Falsification/Fabrication of Data · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · Jagadeesh Rao named as responsible for misconduct
- RetractedRetraction.2016
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Overactivation of G-protein-mediated functions and altered G-protein regulation have been reported in bipolar disorder (BD) brain. Further, drugs effective in treating BD are reported to up-regulate expression of G-protein receptor kinase (GRK) 3 in rat frontal cortex. We therefore hypothesized that some G-protein subunits and GRK levels would be reduced in the brain of BD patients. We determined protein and mRNA levels of G-protein beta and gamma subunits, GRK2, and GRK3 in post-mortem frontal cortex from 10 BD patients and 10 age-matched controls by using immunoblots and real-time RT-PCR. There were statistically significant decreases in protein and mRNA levels of G-protein subunits beta and gamma and of GRK3 in BD brain but not a significant difference in the GRK2 level. Decreased expression of G-protein subunits and of GRK3 may alter neurotransmission, leading to disturbed cognition and behaviour in BD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.