ArticleMolecular microbiology2009
Peptide alarmone signalling triggers an auto-active bacteriocin necessary for genetic competence.
Article in Molecular microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 165 citations in OpenAlex.
- Computational Identification of Novel Transcriptional Regulators and Functional Gene Clusters inMicroorganisms · 2026Article
- Quorum sensing in streptococci and its peptide-mediated modulation.Bioscience reports · 2026Review
- AJournal of bacteriology · 2026Review
- Porphyromonas gingivalis produces a functional HemH ferrochelatase important for its survival in a heme-limited environment.Scientific reports · 2026Article
- Deciphering the role of SMU.1147 in peptide-mediated signaling and competence inMicrobiology spectrum · 2025Article
- Exploring heme and iron acquisition strategies of Porphyromonas gingivalis-current facts and hypotheses.FEMS microbiology reviews · 2025Review
- Insight into the environmental cues modulating the expression of bacterial toxin-antitoxin systems.FEMS microbiology reviews · 2025Review
- Transcriptome Analysis ofGenes · 2023Article
- Identification of a Novel Gene Involved in Cell-to-cell Communication-induced Cell Death and eDNA Production in Streptococcus mutans.Microbes and environments · 2023Article
- The quorum sensing peptide BlpC regulates the transcription of genes outside its associated gene cluster and impacts the growth ofFrontiers in microbiology · 2023Article
- Article
- Rapid Isolation and Purification of Secreted Bacteriocins fromBio-protocol · 2020Article
- Competence-Stimulating-Peptide-Dependent Localized Cell Death and Extracellular DNA Production in Streptococcus mutans Biofilms.Applied and environmental microbiology · 2020Article
- Genetic Analysis of Mutacin B-Ny266, a Lantibiotic Active against Caries Pathogens.Journal of bacteriology · 2020Article
- Novel Probiotic Mechanisms of the Oral BacteriumApplied and environmental microbiology · 2019Article
- Carbohydrate and PepO control bimodality in competence development by Streptococcus mutans.Molecular microbiology · 2019Article
- The Biology ofMicrobiology spectrum · 2019Article
- Expanding the Vocabulary of Peptide Signals inFrontiers in cellular and infection microbiology · 2019Review
- Competence inFrontiers in cellular and infection microbiology · 2019Review
- Genomic, Phenotypic, and Virulence Analysis ofInfection and immunity · 2019Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The induction of genetic competence is a strategy used by bacteria to increase their genetic repertoire under stressful environmental conditions. Recently, Streptococcus pneumoniae has been shown to co-ordinate the uptake of transforming DNA with fratricide via increased expression of the peptide pheromone responsible for competence induction. Here, we document that environmental stress-induced expression of the peptide pheromone competence-stimulating peptide (CSP) in the oral pathogen Streptococcus mutans. We showed that CSP is involved in the stress response and determined the CSP-induced regulon in S. mutans by microarray analysis. Contrary to pneumococcus, S. mutans responds to increased concentrations of CSP by cell lysis in only a fraction of the population. We have focused on the mechanism of cell lysis and have identified a novel bacteriocin as the 'death effector'. Most importantly, we showed that this bacteriocin causes cell death via a novel mechanism of action: intracellular action against self. We have also identified the cognate bacteriocin immunity protein, which resides in a separate unlinked genetic locus to allow its differential regulation. The role of the lytic response in S. mutans competence is also discussed. Together, these findings reveal a novel autolytic pathway in S. mutans which may be involved in the dissemination of fitness-enhancing genes in the oral biofilm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.