ArticleMolecular microbiology2009
AglZ regulates adventurous (A-) motility in Myxococcus xanthus through its interaction with the cytoplasmic receptor, FrzCD.
Article in Molecular microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays.PLoS genetics · 2019Article
- The nucleoid as a scaffold for the assembly of bacterial signaling complexes.PLoS genetics · 2017Article
- Hypothetical Protein BB0569 Is Essential for Chemotaxis of the Lyme Disease Spirochete Borrelia burgdorferi.Journal of bacteriology · 2015Article
- The small G-protein MglA connects to the MreB actin cytoskeleton at bacterial focal adhesions.The Journal of cell biology · 2015Article
- Different effects of MglA and MglB on pilus-mediated functions and natural competence in Thermus thermophilus.Extremophiles : life under extreme conditions · 2015Article
- The cognitive cell: bacterial behavior reconsidered.Frontiers in microbiology · 2015Review
- Dual biochemical oscillators may control cellular reversals in Myxococcus xanthus.Biophysical journal · 2014Article
- Transmission of a signal that synchronizes cell movements in swarms of Myxococcus xanthus.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Ras GTPase-like protein MglA, a controller of bacterial social-motility in Myxobacteria, has evolved to control bacterial predation by Bdellovibrio.PLoS genetics · 2014Article
- Functional organization of a multimodular bacterial chemosensory apparatus.PLoS genetics · 2014Article
- Flagella stator homologs function as motors for myxobacterial gliding motility by moving in helical trajectories.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- MasABK proteins interact with proteins of the type IV pilin system to affect social motility of Myxococcus xanthus.PloS one · 2013Article
- Emergence and modular evolution of a novel motility machinery in bacteria.PLoS genetics · 2011Article
- Motor-driven intracellular transport powers bacterial gliding motility.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Myxobacteria gliding motility requires cytoskeleton rotation powered by proton motive force.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Uncovering the mystery of gliding motility in the myxobacteria.Annual review of genetics · 2011Review
- Myxobacteria, polarity, and multicellular morphogenesis.Cold Spring Harbor perspectives in biology · 2010Review
- A multi-protein complex from Myxococcus xanthus required for bacterial gliding motility.Molecular microbiology · 2010Article
- Gliding motility revisited: how do the myxobacteria move without flagella?Microbiology and molecular biology reviews : MMBR · 2010Review
- Localization of MglA, an essential gliding motility protein in Myxococcus xanthus.Cytoskeleton (Hoboken, N.J.) · 2010Article
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3 authors.
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Abstract
Myxococcus xanthus moves by gliding motility powered by type IV pili (S-motility) and distributed motor complexes (A-motility). The Frz chemosensory pathway controls reversals for both motility systems. However, it is unclear how the Frz pathway can communicate with these different systems. In this article, we show that FrzCD, the Frz pathway receptor, interacts with AglZ, a protein associated with A-motility. Affinity chromatography and cross-linking experiments showed that the FrzCD-AglZ interaction occurs between the uncharacterized N-terminal region of FrzCD and the N-terminal pseudo-receiver domain of AglZ. Fluorescence microscopy showed AglZ-mCherry and FrzCD-GFP localized in clusters that occupy different positions in cells. To study the role of the Frz system in the regulation of A-motility, we constructed aglZ frzCD double mutants and aglZ frzCD pilA triple mutants. To our surprise, these mutants, predicted to show no A-motility (A-S+) or no motility at all (A-S-), respectively, showed restored A-motility. These results indicate that AglZ modulates a FrzCD activity that inhibits A-motility. We hypothesize that AglZ-FrzCD interactions are favoured when cells are isolated and moving by A-motility and inhibited when S-motility predominates and A-motility is reduced.
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