ArticleWorld journal of gastroenterology2009
High level of ezrin expression in colorectal cancer tissues is closely related to tumor malignancy.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Ezrin Inhibition Overcomes Acquired Resistance to Vemurafenib in BRAFV600E-Mutated Colon Cancer and Melanoma Cells In Vitro.International journal of molecular sciences · 2023Article
- Article
- Bidirectional Tumor-Promoting Activities of Macrophage Ezrin.International journal of molecular sciences · 2020Article
- Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway.Autophagy · 2020Article
- Immunohistochemical Study of Ezrin Expression in Colorectal Carcinoma: A Comparative Study between Objective Method and Digital Quantitative Assessment.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Pancreatic cancer-derived small extracellular vesical Ezrin regulates macrophage polarization and promotes metastasis.American journal of cancer research · 2020Article
- High expression of EZR (ezrin) gene is correlated with the poor overall survival of breast cancer patients.Thoracic cancer · 2019Article
- Role of phospho-ezrin in differentiating thyroid carcinoma.Scientific reports · 2019Article
- TGFβ and IGF1R signaling activates protein kinase A through differential regulation of ezrin phosphorylation in colon cancer cells.The Journal of biological chemistry · 2018Article
- Successful identification of a predictive biomarker for lymph node metastasis in colorectal cancer using a proteomic approach.Oncotarget · 2017Article
- Association of Ezrin expression with the progression and prognosis of gastrointestinal cancer: a meta-analysis.Oncotarget · 2017Article
- Ezrin expression and cell survival regulation in colorectal cancer.Cellular signalling · 2014Article
- Increase in ezrin expression from benign to malignant breast tumours.Cellular oncology (Dordrecht, Netherlands) · 2013Article
- Ezrin expression is an independent prognostic factor in gastro-intestinal cancers.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2013Article
- Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells.PloS one · 2013Article
- Ezrin expression in rectal cancer predicts time to development of local recurrence.International journal of colorectal disease · 2012Article
- Ezrin expression as a prognostic marker in colorectal adenocarcinoma.Pathology oncology research : POR · 2011Article
- Up-regulation of hnRNP A1, Ezrin, tubulin β-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer.World journal of gastroenterology · 2010Article
- Enumerating the gene sets in breast cancer, a "direct" alternative to hierarchical clustering.BMC genomics · 2010Article
- Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells.Journal of cell science · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the ezrin expression in normal colorectal mucosa and colorectal cancer tissues, and study the correlation between ezrin expression in colorectal cancer tissues and tumor invasion and metastasis.
methodsEighty paraffin-embedded cancer tissue samples were selected from primary colorectal adenocarcinoma. Twenty-eight patients had well-differentiated, 22 had moderately differentiated and 30 had poorly differentiated adenocarcinoma. Forty-five patients and 35 patients had lymph node metastasis. Forty-five patients were of Dukes A to B stage, and 35 were of C to D stage. Another 22 paraffin-embedded tissue blocks of normal colorectal epithelium (> 5 cm away from the edge of the tumor) were selected as the control group. All patients with colorectal cancer were treated surgically and diagnosed histologically, without preoperative chemotherapy or radiotherapy. The immunohistochemistry was used to detect the ezrin expression in paraffin-embedded normal colorectal mucosa tissues and colorectal cancer tissue samples.
resultsEzrin expression in colorectal cancer was significantly higher than in normal colorectal mucosa (75.00% vs 9.09%, P < 0.01), and there was a close relationship between ezrin expression and the degree of tumor differentiation, lymph node metastasis and Dukes stage (88.46% vs 50.00%, P < 0.01; 94.28% vs 51.11%, P < 0.01; 94.28% vs 51.11%, P < 0.01).
conclusionEzrin expression is obviously higher in colorectal cancer tissues than in normal colorectal mucosa tissues, and the high level of ezrin expression is closely related to the colorectal cancer invasion and metastasis process.
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