ArticleWorld journal of gastroenterology2009
Rocket "Eruca sativa": a salad herb with potential gastric anti-ulcer activity.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 127 citations in OpenAlex.
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- Salt-Affected Rocket Plants as a Possible Source of Glucosinolates.International journal of molecular sciences · 2023Article
- Potential Active Constituents fromPharmaceuticals (Basel, Switzerland) · 2022Article
- Biosynthesized Silver Nanoparticles fromAntibiotics (Basel, Switzerland) · 2022Article
- Sorting biotic and abiotic stresses on wild rocket by leaf-image hyperspectral data mining with an artificial intelligence model.Plant methods · 2022Article
- Phytochemical and In Silico ADME/Tox Analysis ofMolecules (Basel, Switzerland) · 2022Article
- Eruca sativa seed extract modulates oxidative stress and apoptosis and up-regulates the expression of Bcl-2 and Bax genes in acrylamide-induced testicular dysfunction in rats.Environmental science and pollution research international · 2021Article
- Hydromethanolic Crude Extract of the Leaf ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Medicinal Plants with Prospective Benefits in the Management of Peptic Ulcer Diseases in Ghana.BioMed research international · 2021Review
- Food intake biomarkers for green leafy vegetables, bulb vegetables, and stem vegetables: a review.Genes & nutrition · 2020Review
- Evaluation of the Anti-Ulcer Activity of Hydromethanolic Crude Extract and Solvent Fractions of the Root ofJournal of experimental pharmacology · 2020Article
- Enterobacteriaceae dominate the core microbiome and contribute to the resistome of arugula (Eruca sativa Mill.).Microbiome · 2019Article
- Hydrogen Sulfide-Mediated Activation ofInternational journal of molecular sciences · 2018Article
- Protective effects of a triple-fermented barley extract (FBe) against HCl/EtOH-induced gastric mucosa damage in mice.Food science & nutrition · 2018Article
- Antiulcer Activity and Potential Mechanism of Action of the Leaves ofOxidative medicine and cellular longevity · 2018Article
- The fatty acid-rich fraction of Eruca sativa (rocket salad) leaf extract exerts antidiabetic effects in cultured skeletal muscle, adipocytes and liver cells.Pharmaceutical biology · 2017Article
- Article
- Synthesis and characterisation of metal nanoparticles and their effects on seed germination and seedling growth in commercially important Eruca sativa.IET nanobiotechnology · 2016Article
- Vanillin abrogates ethanol induced gastric injury in rats via modulation of gastric secretion, oxidative stress and inflammation.Toxicology reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo validate gastric anti-ulcer properties of Rocket "Eruca sativa" on experimentally-induced gastric secretion and ulceration in albino rats.
methodsGastric acid secretion studies were undertaken using pylorus-ligated rats. Gastric lesions in the rats were induced by noxious chemicals including ethanol, strong alkalis, indomethacin and hypothermic restraint stress. The levels of gastric wall mucus (GWM), nonprotein sulfhydryls (NP-SH) and malondialdehyde (MDA) were also measured in the glandular stomach of rats following ethanol administration. The gastric tissue was also examined histologically. The extract was used in two doses (250 and 500 mg/kg body weight) in all experiments.
resultsIn pylorus-ligated Shay rats, the ethanolic extract of Rocket "Eruca sativa L." (EER) significantly and dose-dependently reduced the basal gastric acid secretion, titratable acidity and ruminal ulceration. Rocket extract significantly attenuated gastric ulceration induced by necrotizing agents (80% ethanol, 0.2 mol/L NaOH, 25% NaCl), indomethacin and hypothermic restraint stress. The anti-ulcer effect was further confirmed histologically. On the other hand, the extract significantly replenished GWM and NP-SH levels, as well as the MDA level significantly reduced by extract pretreatment.
conclusionRocket extract possesses anti-secretory, cytoprotective, and anti-ulcer activities against experimentally-induced gastric lesions. The anti-ulcer effect is possibly through prostaglandin-mediated activity and/or through its anti-secretory and antioxidant properties.
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Registered trials
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