ArticleAnnals of neurology2009
Varicella zoster virus is not a disease-relevant antigen in multiple sclerosis.
Article in Annals of neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- SARS-CoV-2 Morbidity in the CNS and the Aged Brain Specific Vulnerability.International journal of molecular sciences · 2022Review
- Review
- EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Viruses and endogenous retroviruses in multiple sclerosis: From correlation to causation.Acta neurologica Scandinavica · 2017Review
- Varicella Zoster Virus Infection in Granulomatous Arteritis of the Aorta.The Journal of infectious diseases · 2016Article
- Detection of varicella-zoster virus DNA during medullary and brainstem relapses in multiple sclerosis.BMJ case reports · 2016Article
- Prevalence and distribution of VZV in temporal arteries of patients with giant cell arteritis.Neurology · 2015Article
- Infection as an Environmental Trigger of Multiple Sclerosis Disease Exacerbation.Frontiers in immunology · 2015Review
- Prevalence of human Herpesviridae in cerebrospinal fluid of patients with multiple sclerosis and noninfectious neurological disease in the Netherlands.Journal of neurovirology · 2014Article
- The fraction of varicella zoster virus-specific antibodies among all intrathecally-produced antibodies discriminates between patients with varicella zoster virus reactivation and multiple sclerosis.Fluids and barriers of the CNS · 2014Article
- Viruses and neurodegeneration.Virology journal · 2013Review
- Viruses and multiple sclerosis.CNS & neurological disorders drug targets · 2012Review
- Article
- Translational Mini-Review Series on B cell subsets in disease. B cells in multiple sclerosis: drivers of disease pathogenesis and Trojan horse for Epstein-Barr virus entry to the central nervous system?Clinical and experimental immunology · 2012Review
- Viruses and multiple sclerosis.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2011Review
- Subclinical reactivation of varicella zoster virus in all stages of HIV infection.Journal of the neurological sciences · 2011Article
- Viral triggers of multiple sclerosis.Biochimica et biophysica acta · 2011Review
- Varicella zoster virus and relapsing remitting multiple sclerosis.Multiple sclerosis international · 2011Article
- Negative association of Epstein-Barr virus or herpes simplex virus-1 with tumefactive central nervous system inflammatory demyelinating disease.Journal of neurovirology · 2010Article
- Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid.Annals of neurology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Herpesvirions and varicella zoster virus (VZV) DNA were recently reported in all 15 cerebrospinal fluid (CSF) samples from patients with relapsing-remitting multiple sclerosis (MS) obtained within 1 week of exacerbation. Using identical electron microscopic and polymerase chain reaction techniques, including additional primer sets representing different regions of the VZV genome, we found no herpesvirions or VZV DNA in MS CSF or acute MS plaques. Although enzyme-linked immunosorbent assay analysis demonstrated a higher titer of VZV antibody in MS CSF than in inflammatory control samples, recombinant antibodies prepared from clonally expanded MS CSF plasma cells did not bind to VZV. VZV is not a disease-relevant antigen in MS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.