ArticleEuropean archives of psychiatry and clinical neuroscience2009
Heritability of Trail Making Test performance in multiplex schizophrenia families: implications for the search for an endophenotype.
Article in European archives of psychiatry and clinical neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 17 citations in OpenAlex.
- Differences in Performance in the Trail Making Test Part B Between Adoptees With High and Low Genetic Risk for Schizophrenia Spectrum Disorders: The Finnish Adoptive Family Study of Schizophrenia.The European journal of neuroscience · 2025Article
- Dopaminergic gene polymorphisms and cognitive function in a north Indian schizophrenia cohort.Journal of psychiatric research · 2013Article
- Prefrontal deviations in function but not volume are putative endophenotypes for schizophrenia.Brain : a journal of neurology · 2012Article
- Longitudinal alterations of executive function in non-psychotic adolescents at familial risk for schizophrenia.Progress in neuro-psychopharmacology & biological psychiatry · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impairment of the Trail Making Test (TMT) performance as a measure of executive function deficits has been found both in patients with schizophrenia and in their unaffected first-degree relatives, suggesting that it might be considered as a familial vulnerability marker, but its heritability estimates are not well known. This study investigated the genetic heritability of impairments in TMT performance using a sample of 80 schizophrenia patients, 145 unaffected first-degree relatives and 127 healthy controls from families with multiple members with schizophrenia. Consistent with previous reports in the literature, relatives performed in between healthy controls and schizophrenia patients. Based on these results, a variance component-analysis provided small, but significant additive heritability estimates for performance indices relating performance in TMT-version A to TMT-version B. These results showed that this significant but small evidence of heritability on the one hand suggests an association with genetic predisposition to schizophrenia, but that TMT performance is also associated with epigenetic or environmental factors.
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Registered trials
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