ReviewInternational journal of molecular sciences2009
Mechanism of suppression of protein aggregation by α-crystallin.
Review in International journal of molecular sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Toxicoproteomic analysis reveals arsenic-induced alterations in eye lens proteins of Labeo rohita.Fish physiology and biochemistry · 2026Article
- Adenosine Triphosphate (ATP) and Protein Aggregation in Age-Related Vision-Threatening Ocular Diseases.Metabolites · 2023Article
- Case report: Fatal infantile hypertonic myofibrillar myopathy with compound heterozygous mutations in theFrontiers in pediatrics · 2022Article
- Drosophila NUAK functions with Starvin/BAG3 in autophagic protein turnover.PLoS genetics · 2020Article
- Application of Circular Dichroism and Fluorescence Spectroscopies To Assess Photostability of Water-Soluble Porcine Lens Proteins.ACS omega · 2020Article
- UV-B induced fibrillization of crystallin protein mixtures.PloS one · 2017Article
- Thermal aggregation of hen egg white proteins in the presence of salts.The protein journal · 2015Article
- Abnormally upregulated αB-crystallin was highly coincidental with the astrogliosis in the brains of scrapie-infected hamsters and human patients with prion diseases.Journal of molecular neuroscience : MN · 2013Article
- Article
- Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update.Archives of toxicology · 2013Review
- Pathology-dependent effects linked to small heat shock proteins expression: an update.Scientifica · 2012Review
- Infantile muscular dystrophy in Canadian aboriginals is an αB-crystallinopathy.Annals of neurology · 2011Article
- A protein aggregation based test for screening of the agents affecting thermostability of proteins.PloS one · 2011Article
- Paradoxical acceleration of dithiothreitol-induced aggregation of insulin in the presence of a chaperone.International journal of molecular sciences · 2010Article
- Thermal denaturation and aggregation of myosin subfragment 1 isoforms with different essential light chains.International journal of molecular sciences · 2010Article
- Comparative analysis of the effects of alpha-crystallin and GroEL on the kinetics of thermal aggregation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase.The protein journal · 2010Article
- GroEL-assisted protein folding: does it occur within the chaperonin inner cavity?International journal of molecular sciences · 2009Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review summarizes experimental data illuminating the mechanism of suppression of heat-induced protein aggregation by alpha-crystallin, one of the small heat shock proteins. The dynamic light scattering data show that the initial stage of thermal aggregation of proteins is the formation of the initial aggregates involving hundreds of molecules of the denatured protein. Further sticking of the starting aggregates proceeds in a regime of diffusion-limited cluster-cluster aggregation. The protective effect of alpha-crystallin is due to transition of the aggregation process to the regime of reaction-limited cluster-cluster aggregation, wherein the sticking probability for the colliding particles becomes lower than unity.
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