Evidence map›Paper›PMID 19398687›Full record

Trial reportArchives of internal medicine2009

Effect of a pharmacist on adverse drug events and medication errors in outpatients with cardiovascular disease.

Michael D Murray, Mary E Ritchey, Jingwei Wu, Wanzhu Tu

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Archives of internal medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. RBMJ open · 2021
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  9. Access to Telepharmacy Services May Reduce Hospital Admissions in Outpatient Populations During the COVID-19 Pandemic.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Michael D MurrayDivision of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, CB 7360, Kerr Hall, Room 2212, Chapel Hill, NC 27599-7360, USA. mick@unc.edu
Mary E Ritchey
Jingwei Wu
Wanzhu Tu

Funding

Improving Medication Use in Patients With HypertensionR01HL069399 · NHLBI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI MURRAY, MICHAEL DENNIS · 2001 to 2004
$2.1M
IMPROVING DRUG USE FOR ELDERLY HEART FAILURE PATIENTSR01AG019105 · NIA · PURDUE UNIVERSITY WEST LAFAYETTE · PI MURRAY, MICHAEL D · 2000 to 2003
$1.5M
NHLBI NIH HHS R01 HL069399NHLBI NIH HHS R01 HL 69399NIA NIH HHS R01 AG19105
6 · The paper itself

Abstract

backgroundAdverse drug events and medication errors are threats to quality care. Inpatient studies suggest that a pharmacist may reduce these events, but outpatient studies have not been forthcoming.

methodsWe conducted a pooled analysis of 2 randomized controlled trials to determine the effect of pharmacist intervention on adverse drug events and medication errors. We studied 800 outpatient cases of hypertension stratified into complicated (n = 535) and uncomplicated (n = 265). Patients in the complicated stratum had heart failure or other cardiovascular complication. Computer programs examined 1-year electronic record data to identify events classified as adverse drug events and preventable or potential adverse drug events. Medication errors included preventable and potential adverse drug events.

resultsOf the 800 participants (mean [SD] age, 59 [10] years), 484 (90.5%) and 258 (97.4%) participants remained in the complicated and uncomplicated strata, respectively, at 12 months. Compared with the control group, the risk of any event was 34% lower in the intervention group (risk ratio, 0.66; 95% confidence interval [CI], 0.50-0.88), including a lower risk of adverse drug events (risk ratio, 0.65; 95% CI, 0.47-0.90), preventable adverse drug events (risk ratio, 0.52; 95% CI, 0.25-1.09), potential adverse drug events (risk ratio, 0.70; 95% CI, 0.40-1.22), and medication errors (risk ratio, 0.63; 95% CI, 0.40-0.98).

conclusionsThis post hoc analysis suggests that pharmacist intervention to improve medication use in outpatients with cardiovascular disease decreases the risk of adverse drug events and medication errors. Further studies are needed to confirm this finding.

Indexed as

PharmacistsAdultAgedAmbulatory CareDrug-Related Side Effects and Adverse ReactionsFemaleHeart FailureHospitals, TeachingHumansHypertensionIndianaMaleMedication ErrorsMiddle Aged

Identifiers

PMID19398687

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.