ArticleAntimicrobial agents and chemotherapy2009
In vitro elution of daptomycin by a synthetic crystallic semihydrate form of calcium sulfate, stimulan.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Role of STIMULAN in chronic osteomyelitis-A randomised blinded study on 95 patients comparing 3 antibiotic compositions, bead quality, forming & absorption time.Journal of clinical orthopaedics and trauma · 2024Article
- Identifying alternative antibiotics that elute from calcium sulfate beads for treatment of orthopedic infections.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Simulated large joint fluid model for evaluating intra-articular antibiotic delivery systems: initial evaluation using antibiotic-loaded calcium sulfate beads.Journal of bone and joint infection · 2022Article
- Elution Profiles of Synthetic CaSOEuropean journal of drug metabolism and pharmacokinetics · 2020Article
- Prevention and Killing Efficacy of Carbapenem ResistantMaterials (Basel, Switzerland) · 2020Article
- Bifocal treatment for peri-articular femoral nonunions: A retrospective case series review.OTA international : the open access journal of orthopaedic trauma · 2019Article
- Evaluation of comparative soft tissue response to bone void fillers with antibiotics in a rabbit intramuscular model.Journal of biomaterials applications · 2019Article
- Development of a Novel Collagen Wound Model To Simulate the Activity and Distribution of Antimicrobials in Soft Tissue during Diabetic Foot Infection.Antimicrobial agents and chemotherapy · 2016Article
- Local release of antibiotics for surgical site infection management using high-purity calcium sulfate: an in vitro elution study.Surgical infections · 2015Article
- Chitosan coating to enhance the therapeutic efficacy of calcium sulfate-based antibiotic therapy in the treatment of chronic osteomyelitis.Journal of biomaterials applications · 2014Article
- Evaluation of two sources of calcium sulfate for a local drug delivery system: a pilot study.Clinical orthopaedics and related research · 2011Article
- Management of acute hematogenous osteomyelitis in children.Expert review of anti-infective therapy · 2010Review
- Calcium sulphate mixed with antibiotics does not decrease efficacy againstJournal of orthopaedicsArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A synthetic crystallic semihydrate form of calcium sulfate, Stimulan, was evaluated as a biodegradable carrier for the daily in vitro elution of daptomycin. Daptomycin and Stimulan were admixed at a ratio of 95:5. Elution lasted for 28 days. Eluted concentrations peaked on days 1 and 11, when the mean values were 1,320.1 and 949.2 microg/ml, respectively. The lowest eluted concentration was detected on day 28. These results support the application of the system described in experimental models of osteomyelitis.
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