Evidence map›Paper›PMID 19398558›Full record

ArticleThe Journal of biological chemistry2009

Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361.

Parmil K Bansal, Ashutosh Mishra, Anthony A High, Rashid Abdulle, Katsumi Kitagawa

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Regulatory Mechanisms of Hsp90.Biochemistry & molecular biology journal · 2017
    Article
  8. Article
  9. Mechanisms of Hsp90 regulation.The Biochemical journal · 2016
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Parmil K BansalDepartment of Molecular Pharmacology, Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-3678, USA.
Ashutosh Mishra
Anthony A High
Rashid Abdulle
Katsumi Kitagawa
St. Jude Children's Research Hospital · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Kinetochore Function and Cell Cycle Progression RevisionR01GM068418 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KITAGAWA, KATSUMI · 2003 to 2012
$2.5M
NCI NIH HHS CA21765NCI NIH HHS P30 CA021765NIGMS NIH HHS GM68418NIGMS NIH HHS R01 GM068418
6 · The paper itself

Abstract

The kinetochore, which consists of centromere DNA and structural proteins, is essential for proper chromosome segregation in eukaryotes. In budding yeast, Sgt1 and Hsp90 are required for the binding of Skp1 to Ctf13 (a component of the core kinetochore complex CBF3) and therefore for the assembly of CBF3. We have previously shown that Sgt1 dimerization is important for this kinetochore assembly mechanism. In this study, we report that protein kinase CK2 phosphorylates Ser(361) on Sgt1, and this phosphorylation inhibits Sgt1 dimerization.

Indexed as

Adaptor Proteins, Signal TransducingAmino Acid SequenceCasein Kinase IIHSP90 Heat-Shock ProteinsHumansKinetochoresMolecular Sequence DataNuclear ProteinsPhosphorylationPlasmidsProtein BindingProtein MultimerizationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSerineTime FactorsAdaptor Proteins, Signal TransducingCasein Kinase IICTF13 protein, S cerevisiaeHSP82 protein, S cerevisiaeHSP90 Heat-Shock ProteinsNuclear ProteinsSaccharomyces cerevisiae ProteinsSerineSGT1 protein, S cerevisiae

Identifiers

PMID19398558
PMCPMC2707205
OpenAlexW2055811175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.