ArticleThe Journal of biological chemistry2009
Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Saccharomyces cerevisiae as a tool for deciphering Hsp90 molecular chaperone function.Essays in biochemistry · 2023Article
- Impact of Co-chaperones and Posttranslational Modifications Toward Hsp90 Drug Sensitivity.Sub-cellular biochemistry · 2023Article
- Cell-cycle phospho-regulation of the kinetochore.Current genetics · 2021Review
- Disruption of barley immunity to powdery mildew by an in-frame Lys-Leu deletion in the essential protein SGT1.Genetics · 2021Article
- Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1.The Journal of biological chemistry · 2017Article
- The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores.Scientific reports · 2017Article
- Regulatory Mechanisms of Hsp90.Biochemistry & molecular biology journal · 2017Article
- Article
- Mechanisms of Hsp90 regulation.The Biochemical journal · 2016Review
- Mutation of essential Hsp90 co-chaperones SGT1 or CNS1 renders yeast hypersensitive to overexpression of other co-chaperones.Current genetics · 2014Article
- Alternative approaches to Hsp90 modulation for the treatment of cancer.Future medicinal chemistry · 2014Article
- Article
- Unravelling the proteomic profile of rice meiocytes during early meiosis.Frontiers in plant science · 2014Article
- Article
- A prescription for 'stress'--the role of Hsp90 in genome stability and cellular adaptation.Trends in cell biology · 2012Review
- Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment.Molecular and cellular biology · 2012Article
- Identification of an Hsp90 mutation that selectively disrupts cAMP/PKA signaling in Saccharomyces cerevisiae.Current genetics · 2012Article
- Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts.Developmental biology · 2012Article
- Post-translational modifications of Hsp90 and their contributions to chaperone regulation.Biochimica et biophysica acta · 2012Review
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The kinetochore, which consists of centromere DNA and structural proteins, is essential for proper chromosome segregation in eukaryotes. In budding yeast, Sgt1 and Hsp90 are required for the binding of Skp1 to Ctf13 (a component of the core kinetochore complex CBF3) and therefore for the assembly of CBF3. We have previously shown that Sgt1 dimerization is important for this kinetochore assembly mechanism. In this study, we report that protein kinase CK2 phosphorylates Ser(361) on Sgt1, and this phosphorylation inhibits Sgt1 dimerization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.