ArticleCerebral cortex (New York, N.Y. : 1991)2009
Gene expression profiling of preplate neurons destined for the subplate: genes involved in transcription, axon extension, neurotransmitter regulation, steroid hormone signaling, and neuronal survival.
Article in Cerebral cortex (New York, N.Y. : 1991), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- A topographic protomap in mouse subplate neurons precedes the onset of sensory experience.Nature communications · 2026Article
- A consensus atlas of human brain development defines cell type-specific maturation trajectories across the lifespan.bioRxiv : the preprint server for biology · 2026Article
- Orchestrated molecular changes of proliferative, migratory-fibrillar, synaptic, and postmigratory compartments align with precocious cortex-type specification in the early human pallium.Journal of anatomy · 2026Article
- Differences in Cajal-Retzius Cell Density and Postnatal Persistence Across Cortical Areas Revealed by a Novel Intersectional Genetic Labeling Approach.The Journal of comparative neurology · 2025Article
- Postnatal persistence of hippocampal Cajal-Retzius cells has a crucial role in the establishment of the hippocampal circuit.Development (Cambridge, England) · 2024Article
- Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis.Nature neuroscience · 2023Article
- Article
- Glutamate released by Cajal-Retzius cells impacts specific hippocampal circuits and behaviors.Cell reports · 2022Article
- Earliest Experience of a Relatively Rare Sound But Not a Frequent Sound Causes Long-Term Changes in the Adult Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- An Early Cortical Progenitor-Specific Mechanism Regulates Thalamocortical Innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Comprehensive characterization of migration profiles of murine cerebral cortical neurons during development using FlashTag labeling.iScience · 2021Article
- Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neurons.PLoS genetics · 2021Article
- Loss of Dmrt5 Affects the Formation of the Subplate and Early Corticogenesis.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Article
- Experience-Dependent Regulation of Cajal-Retzius Cell Networks in the Developing and Adult Mouse Hippocampus.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Reelin Prevents Apical Neurite Retraction during Terminal Translocation and Dendrite Initiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Spontaneous Network Activity and Synaptic Development.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Analysis of preplate splitting and early cortical development illuminates the biology of neurological disease.Frontiers in pediatrics · 2014Review
- Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The significance of the subplate for evolution and developmental plasticity of the human brain.Frontiers in human neuroscience · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During mammalian corticogenesis a series of transient cell layers establish laminar architectonics. The preplate, which forms from the earliest-generated neurons, separates into the marginal zone and subplate layer. To provide a systematic screen for genes involved in subplate development and function, we screened lines of transgenic mice, generated using bacterial artificial chromosome methodology (GENSAT Project), to identify transgenic lines of mice that express the enhanced green fluorescent protein (EGFP) reporter in preplate neurons destined for the subplate. Gene expression profiling of RNA purified from EGFP-positive neurons identified over 200 genes with enriched expression in future subplate neurons. Major classes of subplate-enriched genes included genes involved in transcriptional processes, cortical development, cell and axon motility, protein trafficking and steroid hormone signaling. Additionally, we identified 10 genes related to degenerative diseases of the cerebral and cerebellar cortex. Cre recombinase-based fate mapping of cells expressing Phosphodiesterase 1c (Pde1c) revealed beta-galactosidase positive cells in the ventricular zone, as well as the subplate, suggesting that subplate neurons and cortical projection neurons may be derived from common progenitors. These experiments therefore reveal genetic markers, which identify subplate neurons from the earliest stages of their development, and genes with enriched expression in subplate neurons during early stages of corticogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.