ReviewCurrent opinion in structural biology2009
Exploiting structural classifications for function prediction: towards a domain grammar for protein function.
Review in Current opinion in structural biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Clustering protein functional families at large scale with hierarchical approaches.Protein science : a publication of the Protein Society · 2024Article
- Quantitative In Silico Evaluation of Allergenic Proteins fromCurrent issues in molecular biology · 2022Article
- A unified statistical model of protein multiple sequence alignment integrating direct coupling and insertions.Biophysics and physicobiology · 2016Article
- Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.Bioinformatics (Oxford, England) · 2015Article
- Common Amino Acid Subsequences in a Universal Proteome--Relevance for Food Science.International journal of molecular sciences · 2015Review
- CATH FunFHMMer web server: protein functional annotations using functional family assignments.Nucleic acids research · 2015Article
- INGA: protein function prediction combining interaction networks, domain assignments and sequence similarity.Nucleic acids research · 2015Article
- Biophysical constraints on the evolution of tissue structure and function.The Journal of physiology · 2014Article
- Article
- Improved performance of sequence search approaches in remote homology detection.F1000Research · 2013Article
- Rebelling for a reason: protein structural "outliers".PloS one · 2013Article
- Article
- Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies.PLoS computational biology · 2012Article
- Composite structural motifs of binding sites for delineating biological functions of proteins.PloS one · 2012Article
- Detailed analysis of function divergence in a large and diverse domain superfamily: toward a refined protocol of function classification.Structure (London, England : 1993) · 2010Article
- Exploring protein structural dissimilarity to facilitate structure classification.BMC structural biology · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The ability to assign function to proteins has become a major bottleneck for comprehensively understanding cellular mechanisms at the molecular level. Here we discuss the extent to which structural domain classifications can help in deciphering the complex relationship between the functions of proteins and their sequences and structures. Structural classifications are particularly helpful in understanding the mosaic manner in which new proteins and functions emerge through evolution. This is partly because they provide reliable and concrete domain definitions and enable the detection of very remote structural similarities and homologies. It is also because structural data can illuminate more clearly the mechanisms by which a broader functional repertoire can emerge during evolution.
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Registered trials
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