ArticleSchizophrenia research2009
Familial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophrenia.
Article in Schizophrenia research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Heritability of Neuropsychological Measures in Schizophrenia and Nonpsychiatric Populations: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2017Pooled it
- Functional Connectivity Biomarkers in Schizophrenia.Advances in neurobiology · 2024Review
- Deviation from expected cognitive ability across psychotic disorders.Schizophrenia research · 2018Article
- Bipolar disorder risk geneJournal of psychiatry & neuroscience : JPN · 2017Article
- Heterozygous deletion of the LRFN2 gene is associated with working memory deficits.European journal of human genetics : EJHG · 2016Article
- Sex differences in familiality effects on neurocognitive performance in schizophrenia.Biological psychiatry · 2013Article
- Prefrontal deviations in function but not volume are putative endophenotypes for schizophrenia.Brain : a journal of neurology · 2012Article
- Heritability of multivariate gray matter measures in schizophrenia.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2012Article
- Cognition-emotion dysinteraction in schizophrenia.Frontiers in psychology · 2012Article
- Genetic influence on the working memory circuitry: behavior, structure, function and extensions to illness.Behavioural brain research · 2011Review
- Genomics and pharmacogenomics of schizophrenia.CNS neuroscience & therapeutics · 2011Review
- The environment and schizophrenia.Nature · 2010Article
- A multimodal assessment of the genetic control over working memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Re: Familial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophrenia.Schizophrenia research · 2010Article
- Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveNeurocognitive impairment was found to be heritable in individuals with schizophrenia and their relatives. However, the heritability of neurocognitive measures in families with and without schizophrenia has not been directly compared. In this study, we examined the genetic structure of clinical and neurocognitive measures in sibling pairs with and without schizophrenia to test the hypothesis that the familial aggregation of such measures may be altered by having schizophrenia.
methodA total of 278 subjects including patients with schizophrenia and their non-psychotic full siblings, healthy controls, and their full siblings were recruited. Heritability was estimated for working memory, episodic memory, executive function and attention, as well as clinical features, such as positive, negative and disorganization symptoms.
resultsMany clinical and cognitive domains were impaired in subjects with schizophrenia and their non psychotic siblings. Negative symptoms, working memory, episodic memory and executive function, but not positive, disorganization symptoms and attention, were found to be significantly heritable in all sibling pairs. However, the heritability of working memory function was significantly (chi(2)((d.f.=6))=13.9, p=.031) decreased in proband sibling pairs (h(2)=.38) as compared to control sibling pairs (h(2)=.95). Significant genetic correlations were observed between negative symptoms and the cluster of working memory, episodic memory and executive function.
conclusionsSeveral neurocognitive measures were heritable in sibling pairs with and without schizophrenia. However, schizophrenia reduced the heritability of working memory, perhaps due to disease-related environmental or genetic factors. Evidence for potential pleiotropy will inform future phenotypic studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.