Evidence map›Paper›PMID 19398140›Full record

ReviewTrends in biotechnology2009

High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research.

Tiago G Fernandes, Maria Margarida Diogo, Douglas S Clark, Jonathan S Dordick, Joaquim M S Cabral

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed.

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  12. Flipped Well-Plate Hanging-Drop Technique for Growing Three-Dimensional Tumors.Frontiers in bioengineering and biotechnology · 2022
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tiago G FernandesInstitute for Biotechnology and Bioengineering (IBB), Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Maria Margarida Diogo
Douglas S Clark
Jonathan S Dordick
Joaquim M S Cabral

Funding

High-Throughput Solid-Phase Combinatorial BiocatalysisR01GM066712 · NIGMS · RENSSELAER POLYTECHNIC INSTITUTE · PI DORDICK, JONATHAN S. · 2004 to 2007
$2.7M
High-Throughput Platform for Identifying Stem Cell ToxicityR01ES020903 · NIEHS · RENSSELAER POLYTECHNIC INSTITUTE · PI DORDICK, JONATHAN S., SCHAFFER, DAVID V · 2012 to 2015
$2.0M
Integrated Biochip for In-Vitro ToxicologyR42ES012619 · NIEHS · SOLIDUS BIOSCIENCES, INC. · PI DORDICK, JONATHAN S. · 2005 to 2007
$1.7M
Integrated Biochip for In-Vitro ToxicologyR41ES012619 · NIEHS · SOLIDUS BIOSCIENCES, INC. · PI DORDICK, JONATHAN S. · 2003 to 2004
$499k
NIEHS NIH HHS ES012619NIEHS NIH HHS R01 ES020903NIEHS NIH HHS R41 ES012619NIEHS NIH HHS R42 ES012619NIGMS NIH HHS GM66712NIGMS NIH HHS R01 GM066712
6 · The paper itself

Abstract

Cellular microarrays are powerful experimental tools for high-throughput screening of large numbers of test samples. Miniaturization increases assay throughput while reducing reagent consumption and the number of cells required, making these systems attractive for a wide range of assays in drug discovery, toxicology, stem cell research and potentially therapy. Here, we provide an overview of the emerging technologies that can be used to generate cellular microarrays, and we highlight recent significant advances in the field. This emerging and multidisciplinary approach offers new opportunities for the design and control of stem cells in tissue engineering and cellular therapies and promises to expedite drug discovery in the biotechnology and pharmaceutical industries.

Indexed as

Stem CellsTissue Array AnalysisAnimalsCellsDrug DiscoveryHumansMicrofluidic Analytical TechniquesOligonucleotide Array Sequence AnalysisToxicity Tests

Identifiers

PMID19398140
PMCPMC5333994

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.