Evidence map›Paper›PMID 19397915›Full record

ArticleJournal of molecular biology2009

Secondary structures for 5' regions of R2 retrotransposon RNAs reveal a novel conserved pseudoknot and regions that evolve under different constraints.

Elzbieta Kierzek, Shawn M Christensen, Thomas H Eickbush, Ryszard Kierzek, Douglas H Turner, Walter N Moss

Abstract read
In one paragraph

Article in Journal of molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. DNA-bound avian R2 non-LTR retrotransposon protein recruits a second R2 protein for genome-protective second-strand nicking.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  2. Review
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  9. Stacking in RNA: NMR of Four Tetramers Benchmark Molecular Dynamics.Journal of chemical theory and computation · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elzbieta KierzekDepartment of Chemistry, University of Rochester, NY 14627-0216, USA.
Shawn M Christensen
Thomas H Eickbush
Ryszard Kierzek
Douglas H Turner
Walter N Moss

Funding

KINETIC AND SPECTROSCOPIC STUDIES OF NUCLEIC ACIDSR01GM022939 · NIGMS · UNIVERSITY OF ROCHESTER · PI TURNER, DOUGLAS H. · 1985 to 2016
$7.6M
Retrotransposon expression within ribosomal gene lociR01GM042790 · NIGMS · UNIVERSITY OF ROCHESTER · PI EICKBUSH, THOMAS H. · 1992 to 2013
$4.8M
NIGMS NIH HHS GM22939NIGMS NIH HHS GM42790NIGMS NIH HHS R01 GM022939NIGMS NIH HHS R01 GM042790
6 · The paper itself

Abstract

Sequences from the 5' region of R2 retrotransposons of four species of silk moth are reported. In Bombyx mori, this region of the R2 messenger RNA contains a binding site for R2 protein and mediates interactions critical to R2 element insertion into the host genome. A model of secondary structure for a segment of this RNA is proposed on the basis of binding to oligonucleotide microarrays, chemical mapping, and comparative sequence analysis. Five conserved secondary structures are identified, including a novel pseudoknot. There is an apparent transition from an entirely RNA structure coding function in most of the 5' segment to a protein coding function near the 3' end. This suggests that local regions evolved under separate functional constraints (structural, coding, or both).

Indexed as

5' Untranslated RegionsAnimalsBase SequenceBombyxModels, MolecularMolecular Sequence DataNucleic Acid ConformationRetroelementsRNA, MessengerSequence Alignment5' Untranslated RegionsRetroelementsRNA, Messenger

Identifiers

PMID19397915
PMCPMC2728621

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.