ArticleCritical care (London, England)2009
Propofol: neuroprotection in an in vitro model of traumatic brain injury.
Article in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Propofol Protects Against Erastin-Induced Ferroptosis in HT-22 Cells.Journal of molecular neuroscience : MN · 2022Article
- Propofol protects against oxygen/glucose deprivation‑induced cell injury via gap junction inhibition in astrocytes.Molecular medicine reports · 2020Article
- Propofol inhibits parthanatos via ROS-ER-calcium-mitochondria signal pathway in vivo and vitro.Cell death & disease · 2018Article
- Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats.Molecular medicine reports · 2016Article
- Desflurane impairs outcome of organotypic hippocampal slices in anMedical gas research · 2016Article
- Propofol Decreases Endoplasmic Reticulum Stress-Mediated Apoptosis in Retinal Pigment Epithelial Cells.PloS one · 2016Article
- Anesthetic Propofol Attenuates Apoptosis, Aβ Accumulation, and Inflammation Induced by Sevoflurane Through NF-κB Pathway in Human Neuroglioma Cells.Cellular and molecular neurobiology · 2015Article
- Effects of blast overpressure on neurons and glial cells in rat organotypic hippocampal slice cultures.Frontiers in neurology · 2015Article
- Endoplasmic reticulum stress is involved in the neuroprotective effect of propofol.Neurochemical research · 2014Article
- The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy.Journal of neurotrauma · 2014Article
- Chronic treatment with anesthetic propofol attenuates β-amyloid protein levels in brain tissues of aged mice.Translational neurodegeneration · 2014Article
- Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice.Journal of Alzheimer's disease : JAD · 2014Article
- Therapeutic hypothermia as a neuroprotective strategy in neonatal hypoxic-ischemic brain injury and traumatic brain injury.Current molecular medicine · 2012Review
- Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore.Medical gas research · 2012Article
- Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury.BMC neurology · 2012Article
- Expression analysis of the early chemokine response 4 h after in vitro traumatic brain injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2011Article
- Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization.PloS one · 2011Article
- Neuroprotective properties of levosimendan in an in vitro model of traumatic brain injury.BMC neurology · 2010Article
- Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury.Critical care (London, England) · 2009Article
- A 6-Step Approach to Gain Higher Quality Results From Organotypic Hippocampal Brain Slices in a Traumatic Brain Injury Model.Basic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe anaesthetic agent propofol (2,6-diisopropylphenol) has been shown to be an effective neuroprotective agent in different in vitro models of brain injury induced by oxygen and glucose deprivation. We examined its neuroprotective properties in an in vitro model of traumatic brain injury.
methodsIn this controlled laboratory study organotypic hippocampal brain-slice cultures were gained from six- to eight-day-old mice pups. After 14 days in culture, hippocampal brain slices were subjected to a focal mechanical trauma and subsequently treated with different molar concentrations of propofol under both normo- and hypothermic conditions. After 72 hours of incubation, tissue injury assessment was performed using propidium iodide (PI), a staining agent that becomes fluorescent only when it enters damaged cells via perforated cell membranes. Inside the cell, PI forms a fluorescent complex with nuclear DNA.
resultsA dose-dependent reduction of both total and secondary tissue injury could be observed in the presence of propofol under both normo- and hypothermic conditions. This effect was further amplified when the slices were incubated at 32 degrees C after trauma.
conclusionsWhen used in combination, the dose-dependent neuroprotective effect of propofol is additive to the neuroprotective effect of hypothermia in an in vitro model of traumatic brain injury.
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