ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology1991
Short-chain fatty acids and CO2 as regulators of Na+ and Cl- absorption in isolated sheep rumen mucosa.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- A meta-analysis of carbon dioxide versus room air insufflation on patient comfort and key performance indicators at colonoscopy.International journal of colorectal disease · 2020Pooled it
- Chicory modulates the rumen environment in lambs with endoparasites.Scientific reports · 2025Article
- Comparative Analysis of Microbial-Short-Chain Fatty Acids-Epithelial Transport Axis in the Rumen Ecosystem Between Tarim Wapiti (Microorganisms · 2025Article
- Effect of zinc oxide nanoparticle supplementation on parasite infection and rumen environment of grazing lambs.Frontiers in veterinary science · 2025Article
- Efficacy of zinc nanoparticle supplementation on ruminal environment in lambs.BMC veterinary research · 2024Article
- Effect of Tea Tree Oil on the Expression of Genes Involved in the Innate Immune System in Goat Rumen Epithelial Cells.Animals : an open access journal from MDPI · 2021Article
- Butyrate Protects Porcine Colon Epithelium from Hypoxia-Induced Damage on a Functional Level.Nutrients · 2021Article
- Butyrate Permeation across the Isolated Ovine Reticulum Epithelium.Animals : an open access journal from MDPI · 2020Article
- Effects of short-term fasting on ruminal pH and volatile fatty acids in cattle fed high-roughage versus high-concentrate diets.The Journal of veterinary medical science · 2020Article
- Intestinal gases: influence on gut disorders and the role of dietary manipulations.Nature reviews. Gastroenterology & hepatology · 2019Review
- Synchronous and Time-Dependent Expression of Cyclins, Cyclin-Dependant Kinases, and Apoptotic Genes in the Rumen Epithelia of Butyrate-Infused Goats.Frontiers in physiology · 2018Article
- Examination of the molecular control of ruminal epithelial function in response to dietary restriction and subsequent compensatory growth in cattle.Journal of animal science and biotechnology · 2016Article
- Rapid Fermentable Substance Modulates Interactions between Ruminal Commensals and Toll-Like Receptors in Promotion of Immune Tolerance of Goat Rumen.Frontiers in microbiology · 2016Article
- Short-term adaptation of the ruminal epithelium involves abrupt changes in sodium and short-chain fatty acid transport.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Epithelia of the ovine and bovine forestomach express basolateral maxi-anion channels permeable to the anions of short-chain fatty acids.Pflugers Archiv : European journal of physiology · 2014Article
- Cultured ruminal epithelial cells express a large-conductance channel permeable to chloride, bicarbonate, and acetate.Pflugers Archiv : European journal of physiology · 2009Article
- Transport of acetate and sodium in sheep omasum: mutual, but asymmetric interactions.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2006Article
- Luminal hyperosmolarity decreases Na transport and impairs barrier function of sheep rumen epithelium.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2005Article
- Effects of seasonal changes in food quality and food intake on the transport of sodium and butyrate across ruminal epithelium of reindeer.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2003Article
- Effect of nitric oxide on electrolyte transport across the porcine proximal colon.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unidirectional 22Na+ and 36Cl- fluxes were determined in short-circuited, stripped rumen mucosa from sheep by using the Ussing chamber technique. In both CO2/HCO3(-)-containing and CO2/HCO3(-)-free solutions, replacement of gluconate by short-chain fatty acids (SCFA, 39mM) significantly enhanced mucosal-to-serosal Na+ absorption without affecting the Cl- transport in the same direction. Short-chain fatty acid stimulation of Na+ transport was at least partly independent of Cl- and could almost completely be abolished by 1 mM mucosal amiloride, while stimulation of Na+ transport was enhanced by lowering the mucosal pH from 7.3 to 6.5. Similar to the SCFA action, raising the PCO2 in the mucosal bathing solution led to an increase in the amiloride-sensitive mucosal-to-serosal Na+ flux. Along with its effect on sodium transport, raising the PCO2 also stimulated chloride transport. The results are best explained by a model in which undissociated SCFA and/or CO2 permeate the cell membrane and produce a raise in intracellular H+ concentration. This stimulates an apical Na+/H+ exchange, leading to increased Na+ transport. The stimulatory effect of CO2 on Cl- transport is probably mediated by a Cl-/HCO3- exchange mechanism in the apical membrane. Binding of SCFA anions to that exchange as described for the rat distal colon (Binder and Mehta 1989) probably does not play a major role in the rumen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.