ReviewFEMS microbiology reviews2009
Pilin gene variation in Neisseria gonorrhoeae: reassessing the old paradigms.
Review in FEMS microbiology reviews, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- Publicly Available Neisseria Gonorrhoeae Genomes Predominantly Represent In Vitro-Derived Nonpiliated Variants.The Journal of infectious diseases · 2026Article
- How and when organisms edit their own genomes.Nature genetics · 2025Review
- Addressing Sexually Transmitted Infections Due toMicroorganisms · 2024Review
- Neisseria gonorrhoeae MlaA influences gonococcal virulence and membrane vesicle production.PLoS pathogens · 2019Article
- Multiscale Immune Selection and the Transmission-Diversity Feedback in Antigenically Diverse Pathogen Systems.The American naturalist · 2018Article
- Proteomics, Bioinformatics and Structure-Function Antigen Mining For Gonorrhea Vaccines.Frontiers in immunology · 2018Review
- Gonorrhea - an evolving disease of the new millennium.Microbial cell (Graz, Austria) · 2016Review
- H-NS suppresses pilE intragenic transcription and antigenic variation in Neisseria gonorrhoeae.Microbiology (Reading, England) · 2016Article
- The Global Transcription Factor Lrp Controls Virulence Modulation in Xenorhabdus nematophila.Journal of bacteriology · 2015Article
- pilS loci in Neisseria gonorrhoeae are transcriptionally active.Microbiology (Reading, England) · 2015Article
- Small transcriptome analysis indicates that the enzyme RppH influences both the quality and quantity of sRNAs in Neisseria gonorrhoeae.FEMS microbiology letters · 2015Article
- Mini-review: Strategies for Variation and Evolution of Bacterial Antigens.Computational and structural biotechnology journal · 2015Review
- Article
- Prevalence and genetic diversity of two adhesion-related genes, pilE and nadA, in Neisseria meningitidis in China.Epidemiology and infection · 2013Article
- Domain exchange at the 3' end of the gene encoding the fratricide meningococcal two-partner secretion protein A.BMC genomics · 2013Article
- Suggested role for G4 DNA in recombinational switching at the antigenic variation locus of the Lyme disease spirochete.PloS one · 2013Article
- Pharmacodynamics, population dynamics, and the evolution of persistence in Staphylococcus aureus.PLoS genetics · 2013Article
- Non-B DB v2.0: a database of predicted non-B DNA-forming motifs and its associated tools.Nucleic acids research · 2013Article
- Type IV pilin proteins: versatile molecular modules.Microbiology and molecular biology reviews : MMBR · 2012Review
- Deletion of one nucleotide within the homonucleotide tract present in the hsdS gene alters the DNA sequence specificity of type I restriction-modification system NgoAV.Journal of bacteriology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Neisseria gonorrhoeae displays considerable potential for antigenic variation as shown in human experimental studies. Various surface antigens can change either by antigenic variation using RecA-dependent recombination schemes (e.g. PilE antigenic variation) or, alternatively, through phase variation (on/off switching) in a RecA-independent fashion (e.g. Opa and lipooligosaccharide phase variation). PilE antigenic variation has been well documented over the years. However, with the availability of the N. gonorrhoeae FA1090 genome sequence, considerable genetic advances have recently been made regarding the mechanistic considerations of the gene conversion event, leading to an altered PilE protein. This review will compare the various models that have been presented and will highlight potential mechanistic problems that may constrain any genetic model for pilE gene variation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.