ArticleUpsala journal of medical sciences2009
Smoking as a product of gene-environment interaction.
Article in Upsala journal of medical sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Parental Smoking in Childhood as a Smoking Risk Factor Throughout Middle Age.American journal of preventive medicine · 2023Article
- Classifying and characterizing nicotine use disorder with high accuracy using machine learning and resting-state fMRI.Addiction biology · 2019Article
- Article
- Parental smoke exposure and the development of nicotine craving in adolescent novice smokers: the roles of DRD2, DRD4, and OPRM1 genotypes.BMC pulmonary medicine · 2015Article
- Childhood adversity, serotonin transporter (5-HTTLPR) genotype, and risk for cigarette smoking and nicotine dependence in alcohol dependent adults.Drug and alcohol dependence · 2012Article
- Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse.Substance abuse and rehabilitation · 2012Article
- Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals.Clinical and experimental medicine · 2012Article
- Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour.Journal of genetics · 2011Review
- 'Smoking genes': a genetic association study.PloS one · 2011Article
- Article
- Contribution of hypothalamic-pituitary-adrenal activity and environmental stress to vulnerability for smoking in adolescents.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Article
- Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays.Scientia pharmaceuticaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A strong hereditary influence on smoking has been demonstrated. As one of the candidate genes in relation to smoking, the serotonin transporter gene (5-HTTLPR) has been suggested, however with conflicting results. In recent studies, it has been shown that genotypic and environmental (G*E) factors interact in the shaping of a variety of phenotypic expressions. The objective of the present study was to investigate the interaction between a variation in the 5-HTTLPR and family environment in relation to smoking habits, nicotine dependence, and nicotine and cotinine levels in hair samples. A random Swedish adolescent population sample (n = 785), from which 200 individuals were stratified regarding behaviour, was genotyped for 5-HTTLPR and assessed with semi-structured interviews, a questionnaire, and hair analyses of nicotine and cotinine. The 5-HTTLPR gene interacted with a poor family environment to predict smoking habits, as well as nicotine and cotinine levels. The risk of being a smoker was increased 13 times for an individual with a combination of the 5-HTTLPR LS genotype and a poor family environment in comparison with the Homozygous Long-Long (LL) genotype and a good family environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.