ArticleCell stress & chaperones2009
Novel Hsp90 partners discovered using complementary proteomic approaches.
Article in Cell stress & chaperones, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- The roles of molecular chaperones in regulating cell metabolism.FEBS letters · 2023Review
- Cytosolic Hsp90 Isoform-Specific Functions and Clinical Significance.Biomolecules · 2022Review
- Regulation of Protein Transport Pathways by the Cytosolic Hsp90s.Biomolecules · 2022Review
- High Expression of Tomm34 and Its Correlations With Clinicopathology in Oral Squamous Cell Carcinoma.Pathology oncology research : POR · 2021Article
- A Chemical Biology Approach to the Chaperome in Cancer-HSP90 and Beyond.Cold Spring Harbor perspectives in biology · 2020Review
- Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.Journal of ovarian research · 2019Article
- Non-enzymatic cleavage of Hsp90 by oxidative stress leads to actin aggregate formation: A novel gain-of-function mechanism.Redox biology · 2019Article
- Adapting to stress - chaperome networks in cancer.Nature reviews. Cancer · 2018Review
- Proteomic interrogation of HSP90 and insights for medical research.Expert review of proteomics · 2017Review
- Article
- Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.Cell chemical biology · 2016Review
- HSP90AB1: Helping the good and the bad.Gene · 2016Review
- The assembly and intermolecular properties of the Hsp70-Tomm34-Hsp90 molecular chaperone complex.The Journal of biological chemistry · 2014Article
- Structural bioinformatics and protein docking analysis of the molecular chaperone-kinase interactions: towards allosteric inhibition of protein kinases by targeting the hsp90-cdc37 chaperone machinery.Pharmaceuticals (Basel, Switzerland) · 2013Article
- Article
- Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes.Beilstein journal of organic chemistry · 2013Article
- Systematic identification of the HSP90 candidate regulated proteome.Molecular & cellular proteomics : MCP · 2012Article
- A chemical cross-linking method for the analysis of binding partners of heat shock protein-90 in intact cells.BioTechniques · 2012Article
- The expanding proteome of the molecular chaperone HSP90.Cell cycle (Georgetown, Tex.) · 2012Article
- Approaches for defining the Hsp90-dependent proteome.Biochimica et biophysica acta · 2012Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hsp90 is an essential eukaryotic molecular chaperone that stabilizes a large set of client proteins, many of which are involved in various cellular signaling pathways. The current list of Hsp90 interactors comprises about 200 proteins and this number is growing steadily. In this paper, we report on the application of three complementary proteomic approaches directed towards identification of novel proteins that interact with Hsp90. These methods are coimmunoprecipitation, pull down with biotinylated geldanamycin, and immobilization of Hsp90beta on sepharose. In all, this study led to the identification of 42 proteins, including 18 proteins that had not been previously characterized as Hsp90 interactors. These novel Hsp90 partners not only represent abundant protein species, but several proteins were identified at low levels, among which signaling kinase Cdk3 and putative transcription factor tripartite motif-containing protein 29. Identification of tetratricopeptide-repeat-containing mitochondrial import receptor protein Tom34 suggests the involvement of Hsp90 in the early steps of translocation of mitochondrial preproteins. Taken together, our data expand the knowledge of the Hsp90 interactome and provide a further step in our understanding of the Hsp90 chaperone system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.