ArticleThe Journal of clinical investigation1991
Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.
Article in The Journal of clinical investigation, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 138 citations in OpenAlex.
- Novel thrombospondin-1 transcript exhibits distinctive expression and activity in thyroid tumorigenesis.Oncogene · 2023Article
- Quercetin Induces Anticancer Activity by Upregulating Pro-NAG-1/GDF15 in Differentiated Thyroid Cancer Cells.Cancers · 2021Article
- Article
- Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family.Biological chemistry · 2010Review
- DNA probe pooling for rapid delineation of chromosomal breakpoints.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- BAC-FISH assays delineate complex chromosomal rearrangements in a case of post-Chernobyl childhood thyroid cancer.Folia histochemica et cytobiologica · 2009Article
- The Role of the PAX8/PPARgamma Fusion Oncogene in Thyroid Cancer.PPAR research · 2008Article
- Fra-1 expression in malignant and benign thyroid tumor.The Korean journal of internal medicine · 2001Article
- Near-haploidy and subsequent polyploidization characterize the progression of peripheral chondrosarcoma.The American journal of pathology · 2000Article
- Evaluation of Endocrine Neoplasms Using Fine Needle Aspiration Biopsy.Endocrine pathology · 2000Article
- DNA copy number changes in thyroid carcinoma.The American journal of pathology · 1999Article
- Comparison of benign and malignant follicular thyroid tumours by comparative genomic hybridization.British journal of cancer · 1998Article
- Recent developments in the investigation of thyroid regulation and thyroid carcinogenesis.Environmental health perspectives · 1998Review
- Differentiated thyroid cancer: determinants of disease progression in patients <21 years of age at diagnosis: a report from the Surgical Discipline Committee of the Children's Cancer Group.Annals of surgery · 1998Article
- Renal Cell Carcinoma Metastatic to the Thyroid Gland: A Comparative Molecular Study Between the Primary and the Metastatic Tumor.Endocrine pathology · 1998Article
- Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets.Nucleic acids research · 1997Article
- Prognostic factors and management in thyroid cancer--consensus or controversy?The Western journal of medicine · 1996Article
- Deletions of the long arm of chromosome 10 in progression of follicular thyroid tumors.Human genetics · 1996Article
- Point mutations of ras and Gs alpha subunit genes in thyroid tumors.Japanese journal of cancer research : Gann · 1995Article
- Allelotyping of follicular thyroid tumors.Human genetics · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytogenetic studies have shown frequent clonal abnormalities in papillary carcinoma (PTC) and follicular carcinoma (FTC). Loss of heterozygosity (LOH) may suggest the presence of tumor suppressor genes and has not been reported in these neoplasms. These studies were undertaken to determine if consistent chromosomal abnormalities are associated with thyroid cancer, to determine likely regions for molecular genetic investigations, and to determine if there is allelic loss in thyroid tumors. Cytogenetic analysis of 26 PTC and 5 FTC showed clonal abnormalities in 9 and included -Y, +5, or inv(10)(q11.2q21.2) in PTC, and -Y or near haploidy in FTC. Using DNA probes specific for chromosomes 1, 3, 10, 16, and 17, we carried out restriction fragment length polymorphism analysis on 6 FTC, 3 follicular adenomas (FA), and 12 PTC. LOH of all informative loci on chromosome 3p was observed in all 6 FTC, but not in FA or PTC. No LOH was observed for loci mapped to chromosome 10 in PTC. Our results suggest: cytogenetic abnormalities of chromosome 10q are associated with PTC; cytogenetic and molecular abnormalities of chromosome 3 are associated with FTC; and a tumor suppressor gene may be present on the short arm of chromosome 3 important for the development or progression of FTC.
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