ArticleThe Journal of clinical investigation1991
Effect of denervation on the expression of two glucose transporter isoforms in rat hindlimb muscle.
Article in The Journal of clinical investigation, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 99 citations in OpenAlex.
- Insulin Resistance Is Not Sustained Following Denervation in Glycolytic Skeletal Muscle.International journal of molecular sciences · 2021Article
- Preclinical rodent models of physical inactivity-induced muscle insulin resistance: challenges and solutions.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Review
- Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease.Pflugers Archiv : European journal of physiology · 2020Review
- Nerve damage induced skeletal muscle atrophy is associated with increased accumulation of intramuscular glucose and polyol pathway intermediates.Scientific reports · 2020Article
- Longitudinal Changes in Glucose Metabolism of Denervated Muscle after Complete Peripheral Nerve Injury.Molecular imaging and biology · 2016Article
- Compensatory responses of the insulin signaling pathway restore muscle glucose uptake following long-term denervation.Physiological reports · 2015Article
- McArdle Disease and Exercise Physiology.Biology · 2014Article
- Cardiovascular autonomic neuropathies as complications of diabetes mellitus.Nature reviews. Endocrinology · 2012Review
- Regulation of GLUT4 expression in denervated skeletal muscle.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle.Molecular endocrinology (Baltimore, Md.) · 2007Article
- Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Role of plasma membrane transporters in muscle metabolism.The Biochemical journal · 2000Review
- Denervation provokes greater reductions in insulin-stimulated glucose transport in muscle than severe diabetes.Molecular and cellular biochemistry · 2000Article
- AML1 is expressed in skeletal muscle and is regulated by innervation.Molecular and cellular biology · 1994Article
- Elevated GLUT 1 level in crude muscle membranes from diabetic Zucker rats despite a normal GLUT 1 level in perineurial sheaths.Diabetologia · 1994Article
- The glucose transporter family: structure, function and tissue-specific expression.The Biochemical journal · 1993Review
- Biochemical and immunocytochemical localization of the 'GLUT5 glucose transporter' in human skeletal muscle.The Biochemical journal · 1992Article
- Expression of MRF4, a myogenic helix-loop-helix protein, produces multiple changes in the myogenic program of BC3H-1 cells.Molecular and cellular biology · 1992Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Denervation rapidly (within 24 h) induces insulin resistance of several insulin-responsive pathways in skeletal muscle, including glucose transport; resistance is usually maximal by 3 d. We examined the effect of denervation on the expression of two glucose transporter isoforms (GLUT-1 and GLUT-4) in rat hindlimb muscle; GLUT-4 is the predominant species in muscle. 1 d postdenervation, GLUT-1 and GLUT-4 mRNA and protein concentrations were unchanged. 3 and 7 d postdenervation, GLUT-4 mRNA and protein (per microgram DNA) were decreased by 50%. The minor isoform, GLUT-1 mRNA increased by approximately 500 and approximately 100%, respectively, on days 3 and 7 while GLUT-1 protein increased by approximately 60 and approximately 100%. The data suggest that the insulin resistance of glucose transport early after denervation does not reflect a decrease in total glucose transporter number; however, decreased GLUT-4 expression may contribute to its increased severity after 3 d. Parallel decreases in GLUT-4 mRNA and GLUT-4 protein postdenervation are consistent with pretranslational regulation; GLUT-1 expression may be regulated pre- and posttranslationally. The cell type(s) which overexpress GLUT-1 postdenervation need to be identified. Nervous stimuli and/or contractile activity may modulate the expression of GLUT-1 and GLUT-4 in skeletal muscle tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.