ReviewMolecular bioSystems2009
Splicing of mRNA precursors: the role of RNAs and proteins in catalysis.
Review in Molecular bioSystems, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Loss of U11/U12 spliceosome geneLife science alliance · 2026Article
- Epitranscriptomic sculpting: the role of mMedical oncology (Northwood, London, England) · 2025Review
- Splicing accuracy varies across human introns, tissues, age and disease.Nature communications · 2025Article
- Transcription factors and splice factors - interconnected regulators of stem cell differentiation.Current stem cell reports · 2023Article
- Simultaneous sequencing of coding and noncoding RNA reveals a human transcriptome dominated by a small number of highly expressed noncoding genes.RNA (New York, N.Y.) · 2018Article
- The catalytically inactive tyrosine phosphatase HD-PTP/PTPN23 is a novel regulator of SMN complex localization.Molecular biology of the cell · 2015Article
- Cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with Prp8.PLoS pathogens · 2014Article
- Investigation of dmyc Promoter and Regulatory Regions.Gene regulation and systems biology · 2013Article
- Spliceosome mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia.Oncotarget · 2012Review
- Defects in spliceosomal machinery: a new pathway of leukaemogenesis.British journal of haematology · 2012Review
- Spliceosome structure and function.Cold Spring Harbor perspectives in biology · 2011Review
- Protein arginine methylation facilitates cotranscriptional recruitment of pre-mRNA splicing factors.Molecular and cellular biology · 2010Article
- Ribonucleoprotein multimers and their functions.Critical reviews in biochemistry and molecular biology · 2010Review
- Identification and characterisation of a novel GHR defect disrupting the polypyrimidine tract and resulting in GH insensitivity.European journal of endocrinology · 2010Article
- Given dimensions of neoplastic events as aberrantly operative alternative splicing.Pathology research international · 2010Article
- Down-regulation of a host microRNA by a viral noncoding RNA.Cold Spring Harbor symposia on quantitative biology · 2010Review
- Model systems: how chemical biologists study RNA.Current opinion in chemical biology · 2009Review
- Rapid cross-linking of an RNA internal loop by the anticancer drug cisplatin.Journal of the American Chemical Society · 2009Article
- The function of spliceosome components in open mitosis.Nucleus (Austin, Tex.)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Splicing of mRNA precursors was discovered over 30 years ago. It is one of the most complex steps in gene expression and therefore must be tightly controlled to ensure that splicing occurs efficiently and accurately. Splicing takes place in a large complex, the spliceosome, which contains approximately 200 proteins and five small RNAs (U snRNAs). Since its discovery, much work has been done to elucidate the pathway of the chemical reaction as well as the proteins and RNAs involved in catalysis. A variety of studies have established the potential for U2 and U6 snRNAs to play a role in splicing catalysis, raising the possibility that the spliceosome is a ribozyme. If correct, this would point to the spliceosomal proteins playing a supporting role during splicing. On the other hand, it may be that proteins contribute more directly to the spliceosomal active site, with the highly evolutionarily conserved Prp8 protein being an excellent candidate. This review will concentrate on recent work on splicing catalysis, and on elucidating the possible roles proteins play in this process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.