ArticleEukaryotic cell2009
Comparative genomics using microarrays reveals divergence and loss of virulence-associated genes in host-specific strains of the insect pathogen Metarhizium anisopliae.
Article in Eukaryotic cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Innate Immunity in Insects: The Lights and Shadows of Phenoloxidase System Activation.International journal of molecular sciences · 2025Review
- Molecular phylogenetic analyses indicate recent divergence of two gryllid-specific lineages within the generalist entomopathogenic fungusMycoscience · 2025Article
- Phylogenetic classification and physiological and ecological traits ofMycoscience · 2024Article
- Activity Against Musca domestica of Hypocrealean Fungi Isolated from Culicids in Central Brazil and Formulated in Vermiculite.Neotropical entomology · 2022Article
- The multifunctional lifestyles of Metarhizium: evolution and applications.Applied microbiology and biotechnology · 2020Review
- Influence of genetic diversity of seventeen Beauveria bassiana isolates from different hosts on virulence by comparative genomics.BMC genomics · 2020Article
- New insights into the evolution of host specificity of threeVirulence · 2020Article
- The entomopathogenic fungus Metarhizium robertsii communicates with the insect host Galleria mellonella during infection.Virulence · 2018Article
- Reprogramming the virulence: Insect defense molecules navigating the epigenetic landscape of Metarhizium robertsii.Virulence · 2018Article
- Article
- Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.BMC genomics · 2015Article
- The influence of conidial Pr1 protease on pathogenicity potential of Metarhizium anisopliae senso latu to ticks.Parasitology research · 2015Article
- Comparative genome analysis of entomopathogenic fungi reveals a complex set of secreted proteins.BMC genomics · 2014Article
- Genetic basis of destruxin production in the entomopathogen Metarhizium robertsii.Current genetics · 2012Article
- Article
- Insertion of an esterase gene into a specific locust pathogen (Metarhizium acridum) enables it to infect caterpillars.PLoS pathogens · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many strains of Metarhizium anisopliae have broad host ranges, but others are specialists and adapted to particular hosts. Patterns of gene duplication, divergence, and deletion in three generalist and three specialist strains were investigated by heterologous hybridization of genomic DNA to genes from the generalist strain Ma2575. As expected, major life processes are highly conserved, presumably due to purifying selection. However, up to 7% of Ma2575 genes were highly divergent or absent in specialist strains. Many of these sequences are conserved in other fungal species, suggesting that there has been rapid evolution and loss in specialist Metarhizium genomes. Some poorly hybridizing genes in specialists were functionally coordinated, indicative of reductive evolution. These included several involved in toxin biosynthesis and sugar metabolism in root exudates, suggesting that specialists are losing genes required to live in alternative hosts or as saprophytes. Several components of mobile genetic elements were also highly divergent or lost in specialists. Exceptionally, the genome of the specialist cricket pathogen Ma443 contained extra insertion elements that might play a role in generating evolutionary novelty. This study throws light on the abundance of orphans in genomes, as 15% of orphan sequences were found to be rapidly evolving in the Ma2575 lineage.
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