ArticleApplied and environmental microbiology2009
In silico prediction of horizontal gene transfer events in Lactobacillus bulgaricus and Streptococcus thermophilus reveals protocooperation in yogurt manufacturing.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Core genome expansion inIranian journal of microbiology · 2025Article
- Microbial interactions and ecology in fermented food ecosystems.Nature reviews. Microbiology · 2025Review
- Antibiotic Resistance Gene Expression in Veterinary Probiotics: Two Sides of the Coin.Veterinary sciences · 2025Review
- Assessment of beneficial effects and identification of host adaptation-associated genes of Ligilactobacillus salivarius isolated from badgers.BMC genomics · 2023Article
- Towards the diversification of lactococcal starter and non-starter species in mesophilic dairy culture systems.Microbial biotechnology · 2023Review
- Transcriptomics ofFrontiers in bioengineering and biotechnology · 2023Article
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- Genomic Insight IntoFrontiers in microbiology · 2022Article
- Host-encoded, cell surface-associated exopolysaccharide required for adsorption and infection by lactococcal P335 phage subtypes.Frontiers in microbiology · 2022Article
- Tyrosine Kinase Self-Phosphorylation Controls Exopolysaccharide Biosynthesis inLife (Basel, Switzerland) · 2021Article
- Traditional Bulgarian Dairy Products: Ethnic Foods with Health Benefits.Microorganisms · 2021Review
- Genome Analysis and Physiological Characterization of FourFrontiers in microbiology · 2020Article
- A Diverse Repertoire of Exopolysaccharide Biosynthesis Gene Clusters inMicroorganisms · 2019Article
- Comparative Genomics ofFrontiers in microbiology · 2019Article
- Conversion of Methionine to Cysteine inFrontiers in microbiology · 2018Article
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- Article
- New Insights into Various Production Characteristics of Streptococcus thermophilus Strains.International journal of molecular sciences · 2016Review
- The Variable Regions of Lactobacillus rhamnosus Genomes Reveal the Dynamic Evolution of Metabolic and Host-Adaptation Repertoires.Genome biology and evolution · 2016Article
- BPGA- an ultra-fast pan-genome analysis pipeline.Scientific reports · 2016Article
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3 authors.
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Abstract
Lactobacillus bulgaricus and Streptococcus thermophilus, used in yogurt starter cultures, are well known for their stability and protocooperation during their coexistence in milk. In this study, we show that a close interaction between the two species also takes place at the genetic level. We performed an in silico analysis, combining gene composition and gene transfer mechanism-associated features, and predicted horizontally transferred genes in both L. bulgaricus and S. thermophilus. Putative horizontal gene transfer (HGT) events that have occurred between the two bacterial species include the transfer of exopolysaccharide (EPS) biosynthesis genes, transferred from S. thermophilus to L. bulgaricus, and the gene cluster cbs-cblB(cglB)-cysE for the metabolism of sulfur-containing amino acids, transferred from L. bulgaricus or Lactobacillus helveticus to S. thermophilus. The HGT event for the cbs-cblB(cglB)-cysE gene cluster was analyzed in detail, with respect to both evolutionary and functional aspects. It can be concluded that during the coexistence of both yogurt starter species in a milk environment, agonistic coevolution at the genetic level has probably been involved in the optimization of their combined growth and interactions.
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