Evidence map›Paper›PMID 19395554›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2009

Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.

Takeshi Nakamura, Hreday N Sapru

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Urocortins in the mammalian endocrine system.Acta veterinaria Scandinavica · 2019
    Review
  4. Article
  5. Article
  6. Mechanisms of cardiovascular actions of urocortins in the hypothalamic arcuate nucleus of the rat.American journal of physiology. Heart and circulatory physiology · 2013
    Article
  7. Bradycardic effects of microinjections of urocortin 3 into the nucleus ambiguus of the rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2012
    Article
  8. Article
  9. Microinjections of urocortin1 into the nucleus ambiguus of the rat elicit bradycardia.American journal of physiology. Heart and circulatory physiology · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Takeshi NakamuraDepartment of Neurological Surgery, MSB H-586, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA.
Hreday N Sapru
Rutgers, The State University of New Jersey · US

Funding

Central Cardiovascular Regulation: Role of Urocortin IIIR01HL024347 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI SAPRU, HREDAY N. · 1985 to 2012
$4.0M
Central Cardiovascular Regulation and Proangiotensin-12R01HL076248 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI SAPRU, HREDAY N. · 2004 to 2013
$3.3M
NHLBI NIH HHS HL024347NHLBI NIH HHS HL076248
6 · The paper itself

Abstract

Urocortin 1 (Ucn1) and urocortin 3 (Ucn3) are new members of the corticotrophin-releasing factor (CRF) peptide family. Ucn1 is a ligand for both the CRF type 1 receptors (CRF(1)Rs) and the CRF type 2 receptors (CRF(2)Rs), whereas Ucn3 is a high-affinity ligand for the CRF(2)Rs. Recently, we reported that Ucn3 microinjections into the medial nucleus tractus solitarius (mNTS) elicit decreases in mean arterial pressure (MAP) and heart rate (HR) (Nakamura T, Kawabe K, Sapru HN. Am J Physiol Heart Circ Physiol 296: H325-H332, 2009). The presence of CRF(2)Rs on afferent terminals has been reported in the mNTS of the rat. It was hypothesized that activation of CRF(2)Rs on afferent terminals in the mNTS may release glutamate, which, in turn, may elicit decreases in MAP and HR via activation of ionotropic glutamate receptors (iGLURs). This hypothesis was tested in urethane-anesthetized, artificially ventilated, adult male Wistar rats. Microinjections (100 nl) of Ucn1 (0.12 mM) into the mNTS elicited decreases in MAP and HR. The responses were partially blocked by microinjections of iGLUR antagonists into the mNTS. On the other hand, the decreases in MAP and HR elicited by microinjections of Ucn3 (0.06 mM) into the mNTS were completely blocked by microinjections of iGLUR antagonists into the mNTS. These results indicate that activation of CRF(2)Rs in the mNTS, by Ucn1 and Ucn3, releases glutamate, which, in turn, elicits decreases in MAP and HR via activation of iGLURs.

Indexed as

Amphibian ProteinsAniline CompoundsAnimalsCorticotropin-Releasing HormoneCRF Receptor, Type 1Excitatory Amino Acid AntagonistsGlutamic AcidHeart RateMaleMicroinjectionsPeptide HormonesPyrimidinesQuinoxalinesRatsRats, WistarReceptors, Corticotropin-Releasing Hormone2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidineAmphibian ProteinsAniline CompoundsCorticotropin-Releasing HormoneCRF Receptor, Type 1CRF receptor type 2Excitatory Amino Acid AntagonistsGlutamic AcidPeptide HormonesPyrimidinesQuinoxalinesReceptors, Corticotropin-Releasing HormoneReceptors, Glutamatesauvagineurocortin 3, ratUrocortins

Identifiers

PMID19395554
PMCPMC2716101
OpenAlexW2165041604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.